| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3789901 | F | Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calcium mobilization pre-incubated for 2.5 mins before glutamate stimulation for 1 min | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
| 2. | ALA3789902 | F | Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calcium mobilization pre-incubated for 2.5 mins before glutamate stimulation for 1 min relative to glutamate alone | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 3. | ALA3789907 | A | Stability in rat liver microsomes | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 4. | ALA3789908 | A | Stability in human liver microsomes | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 5. | ALA3789909 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA3789910 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA3789911 | A | Plasma in clearance in rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3789912 | A | Volume of distribution in rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3789913 | A | Half life in rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3790231 | A | Plasma protein binding in human | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA3790232 | A | Plasma protein binding in rat | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA3790233 | A | Protein binding in rat brain | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA3790234 | A | Fraction unbound in human plasma | Homo sapiens | 13 | cell-free format | Scientific Literature | ||
| 14. | ALA3790235 | A | Fraction unbound in rat plasma | Rattus norvegicus | 13 | cell-free format | Scientific Literature | ||
| 15. | ALA3790236 | A | Inhibition of CYP34A (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA3790237 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA3790238 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA3790239 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3790240 | F | Positive allosteric modulatory activity at human mGlu4 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calcium mobilization pre-incubated for 2.5 mins before glutamate stimulation for 1 min | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA3790241 | A | Ratio of drug level in brain to plasma in rat | Rattus norvegicus | 1 | cell-free format | Scientific Literature |
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