# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3788408 | Functional | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay | Homo sapiens | 26 | ALA3784979 | cell-based format | Scientific Literature | |
2. | ALA3788409 | Functional | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | Homo sapiens | 26 | ALA3784979 | cell-based format | Scientific Literature | |
3. | ALA3788410 | Functional | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | Homo sapiens | 26 | ALA3784979 | cell-based format | Scientific Literature | |
4. | ALA3788411 | Functional | Potency index, ratio of 5-fluorouracil IC50 to compound IC50 for human HCT116 cells | Homo sapiens | 2 | ALA3784979 | cell-based format | Scientific Literature | |
5. | ALA3788655 | Functional | Antiproliferative activity against p53 deficient human HCT116 cells after 48 hrs by MTT assay | Homo sapiens | 7 | ALA3784979 | cell-based format | Scientific Literature | |
6. | ALA3788656 | Functional | Cell cycle arrest in human HCT116 cells assessed as accumulation at G1 phase at 0.06 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 31.72 +/- 2.21%) | Homo sapiens | 1 | ALA3784979 | cell-based format | Scientific Literature | |
7. | ALA3788660 | Functional | Cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 0.06 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 40.55 +/- 1.36%) | Homo sapiens | 1 | ALA3784979 | cell-based format | Scientific Literature | |
8. | ALA3792061 | Functional | Cell cycle arrest in human HCT116 cells assessed as accumulation at G2 phase at 0.06 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 27.73 +/- 3.56%) | Homo sapiens | 1 | ALA3784979 | cell-based format | Scientific Literature | |
9. | ALA3792065 | Binding | Inhibition of MDM2/P53 protein interaction in human HCT116 cells at 0.1 to 1 uM after 24 hrs by immunoprecipitation analysis | Homo sapiens | 2 | ALA3784979 | cell-based format | Scientific Literature | |
10. | ALA3792067 | Toxicity | Toxicity in ip dosed BALB/c mouse by bliss test | Mus musculus | 3 | ALA3784979 | organism-based format | Scientific Literature | |
11. | ALA3792070 | Functional | Antitumor activity against human HCT116 cells xenografted in ip dosed BALB/c mouse assessed as tumor growth inhibition administered twice weekly for 4 weeks measured 24 hrs post last dose | Homo sapiens | 3 | ALA3784979 | organism-based format | Scientific Literature | |
12. | ALA3792071 | Toxicity | Toxicity in BALB/c mouse assessed as change in body weight at 100 to 200 mg/kg, ip twice weekly for 4 weeks measured 24 hrs post last dose | Mus musculus | 3 | ALA3784979 | organism-based format | Scientific Literature |