| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3790123 | F | Induction of glucosuria in Sprague-Dawley rat assessed as increase in glucose excretion per 200 g body weight at 50 mg/kg, administered as single dose via oral gavage after 24 hrs by oral glucose tolerance test (Rvb = 0.23 mg) | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 2. | ALA3790124 | B | Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method | Homo sapiens | 36 | ALA3784944 | cell-based format | Scientific Literature | |
| 3. | ALA3790125 | B | Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method | Homo sapiens | 13 | ALA3784944 | cell-based format | Scientific Literature | |
| 4. | ALA3790126 | B | Selectivity ratio of EC50 for human SGLT1 expressed in CHO-K1 cells to EC50 for human SGLT2 expressed in CHO-K1 cells | Homo sapiens | 13 | ALA3784944 | cell-based format | Scientific Literature | |
| 5. | ALA3790127 | A | Half life in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 6. | ALA3790128 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection measured at 2 to 5 mins post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 7. | ALA3790129 | A | Clearance in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection measured at 2 to 5 mins post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 8. | ALA3790397 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection measured at 2 to 5 mins post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 9. | ALA3790398 | A | Half life in Sprague-Dawley rat at 1.1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 10. | ALA3792100 | A | Cmax in Sprague-Dawley rat at 1.1 mg/kg, po measured at 15 mins to 24 hrs post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 11. | ALA3792101 | A | Tmax in Sprague-Dawley rat at 1.1 mg/kg, po measured at 15 mins to 24 hrs post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 12. | ALA3792102 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1.1 mg/kg, po measured at 15 mins to 24 hrs post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 13. | ALA3792103 | A | Oral bioavailability in Sprague-Dawley rat at 1.1 mg/kg measured at 15 mins to 24 hrs after drug challenge by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 14. | ALA3792105 | F | Reduction of blood glucose level in Sprague-Dawley rat at 50 mg/kg, po administered as single dose via oral gavage after 0.5 to 1 hr by oral glucose tolerance test | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature | |
| 15. | ALA3792106 | F | Effect on glucose AUC in Sprague-Dawley rat at 50 mg/kg, po administered as single dose via oral gavage after 0.5 to 1 hr by oral glucose tolerance test | Rattus norvegicus | 1 | ALA3784944 | organism-based format | Scientific Literature |
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