# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3796544 | B | Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA3792350 | cell-based format | Scientific Literature | |
2. | ALA3796549 | A | Cmax in C57Bl/6 mouse at 3 mg/kg administered via oral gavage by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
3. | ALA3796551 | A | AUC in C57Bl/6 mouse at 3 mg/kg administered via oral gavage by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
4. | ALA3796620 | A | Volume of distribution at steady state in C57Bl/6 mouse at 1 mg/kg, iv as bolus dose by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
5. | ALA3796622 | A | Clearance in C57Bl/6 mouse at 1 mg/kg, iv as bolus dose by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
6. | ALA3796624 | A | Half life in C57Bl/6 mouse at 1 mg/kg, iv as bolus dose by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
7. | ALA3796626 | A | Oral bioavailability in C57Bl/6 mouse at 3 mg/kg administered via oral gavage by LC-MS/MS analysis | Mus musculus | 2 | ALA3792350 | organism-based format | Scientific Literature | |
8. | ALA4121798 | F | Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA4118129 | cell-based format | Scientific Literature | |
9. | ALA5247704 | F | Invivo agonist activity at TGR5 in C57BL/6 mouse assessed as fold increase in GLP-1 secretion at 30 mg/kg, po relative to control | Mus musculus | 1 | ALA5247574 | organism-based format | Scientific Literature | |
10. | ALA5247705 | B | Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion | Homo sapiens | 1 | ALA5247574 | cell-based format | Scientific Literature | |
11. | ALA5247706 | B | Agonist activity at TGR5 in human HEK293 cells incubated for 30 mins | Homo sapiens | 2 | ALA5247574 | cell-based format | Scientific Literature |