Antileishmanial activity against beta-lactamase expressing Leishmania amazonensis amastigotes overnight infected in CD1 mouse macrophages incubated for 72 hrs by nitrocefin dye based assay
Selectivity index, ratio of IC50 for cytotoxic activity against mouse J774 cells to IC50 for antileishmanial activity against Leishmania amazonensis amastigotes
Antileishmanial activity against Leishmania donovani LV82 promastigotes infected in BALB/c mouse model of visceral leishmaniasis assessed as suppression of liver parasitemia at 30 mg/kg/day, ip QD administered 1 week post infection for 5 consecutive days and measured 2 weeks post infection
Antileishmanial activity against Leishmania donovani LV82 promastigotes infected in BALB/c mouse model of visceral leishmaniasis assessed as suppression of liver parasitemia at 50 mg/kg/day, po QD administered 1 week post infection for 5 consecutive days and measured 2 weeks post infection
Antileishmanial activity against Leishmania donovani LV82 promastigotes infected in BALB/c mouse model of visceral leishmaniasis assessed as suppression of liver parasitemia at 100 mg/kg/day, po QD administered 1 week post infection for 5 consecutive days and measured 2 weeks post infection
Antileishmanial activity against beta-lactamase expressing Leishmania amazonensis amastigotes overnight infected in CD1 mouse macrophages incubated for 72 hrs by nitrocefin dye based assay in absence of posaconazole
Antileishmanial activity against beta-lactamase expressing Leishmania amazonensis amastigotes overnight infected in CD1 mouse macrophages incubated for 72 hrs by nitrocefin dye based assay in presence of posaconazole