# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3794880 | Functional | Antileishmanial activity against beta-lactamase expressing Leishmania amazonensis amastigotes overnight infected in CD1 mouse macrophages incubated for 72 hrs by nitrocefin dye based assay | Leishmania amazonensis | 19 | ALA3792273 | organism-based format | Scientific Literature | |
2. | ALA3794881 | Functional | Antileishmanial activity against beta-lactamase expressing Leishmania donovani infected in CD1 mouse macrophages by Giemsa staining base method | Leishmania donovani | 18 | ALA3792273 | organism-based format | Scientific Literature | |
3. | ALA3794882 | ADME | Cytotoxic activity against mouse J774A.1 cells incubate for 72 hrs by MTT assay | Mus musculus | 18 | ALA3792273 | cell-based format | Scientific Literature | |
4. | ALA3794883 | Toxicity | Selectivity index, ratio of IC50 for cytotoxic activity against mouse J774 cells to IC50 for antileishmanial activity against Leishmania amazonensis amastigotes | 7 | ALA3792273 | cell-based format | Scientific Literature | ||
5. | ALA3794884 | Toxicity | Selectivity index, ratio of IC50 for cytotoxic activity against mouse J774 cells to IC50 for antileishmanial activity against Leishmania donovani | 7 | ALA3792273 | cell-based format | Scientific Literature | ||
6. | ALA3794885 | Toxicity | Toxicity in BALB/c mouse assessed as drug tolerance at 30 mg/kg/day, ip for 5 days | Mus musculus | 3 | ALA3792273 | organism-based format | Scientific Literature | |
7. | ALA3794886 | Functional | Antileishmanial activity against Leishmania donovani LV82 promastigotes infected in BALB/c mouse model of visceral leishmaniasis assessed as suppression of liver parasitemia at 30 mg/kg/day, ip QD administered 1 week post infection for 5 consecutive days and measured 2 weeks post infection | Leishmania donovani | 3 | ALA3792273 | organism-based format | Scientific Literature |