| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3795929 | B | Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA3795930 | A | Cytotoxicity against human HepG2 cells assessed as rate of ATP content at 30 uM after 1 day by ATPLite-M assay relative to control | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 3. | ALA3795931 | F | Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-stimulated cAMP accumulation after 4 hrs by steady-glo luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3795932 | B | Binding affinity to human CRF2alpha receptor up to 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA3795933 | B | Binding affinity to human CRF2beta receptor up to 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3795934 | P | Solubility of the compound in pH 6.8 phosphate buffer with bile acid by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA3795935 | F | Ex vivo inhibition of [125I]-CRF binding to CRF1 receptor in mouse frontal cortex at 60 mg/kg, po after 1 hr by gamma scintillation counting method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3795937 | F | Ex vivo inhibition of [125I]-CRF binding to CRF1 receptor in mouse olfactory bulb at 60 mg/kg, po after 1 hr by gamma scintillation counting method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3795939 | F | Ex vivo inhibition of [125I]-CRF binding to CRF1 receptor in mouse pituitary gland at 60 mg/kg, po after 1 hr by gamma scintillation counting method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3796017 | F | Suppression of stress-induced activation of hypothalamus-pituitary-adrenocortical axis in mouse assessed as reduction of plasma ATCH level at 60 mg/kg, po after 1 hr by immunoradiometric assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4002315 | B | Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes after 1.5 hrs by liquid scintillation counting method | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 12. | ALA4002316 | A | Clearance in human hepatic microsomes at 1 umol/L after 20 mins in presence of NADPH generating system by UV detector-based HPLC method | Homo sapiens | 16 | assay format | Scientific Literature |
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