| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3796330 | B | Inhibition of Influenza A virus PR/8/34 6His-tagged PA (239 to 716 residues) interaction with GST-tagged PB1 (1 to 25 residues) expressed in Escherichia coli compound treated in PBS buffer measured after overnight incubation by ELISA | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 18 | assay format | Scientific Literature | ||
| 2. | ALA3796331 | F | Antiviral activity against Influenza A virus PR/8/34 infected in MDCK cells assessed as inhibition of plaque formation treated for 1 hr measured after 2 days by toluidine blue staining-based assay | Influenza A virus | 18 | organism-based format | Scientific Literature | ||
| 3. | ALA3796332 | A | Cytotoxicity against HEK293T cells assessed as decrease in cell viability after 24 hrs by MTT assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA3796333 | A | Cytotoxicity against MDCK cells assessed as decrease in cell viability after 48 hrs by MTT assay | Canis lupus familiaris | 18 | cell-based format | Scientific Literature | ||
| 5. | ALA3796334 | B | Inhibition of Influenza A virus PR/8/34 6His-tagged PA (239 to 716 residues) interaction with GST-tagged PB1 (1 to 25 residues) expressed in Escherichia coli compound treated in DMEM serum-free medium measured after overnight incubation by ELISA | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 7 | assay format | Scientific Literature | ||
| 6. | ALA3796335 | B | Inhibition of Influenza A virus RdRp transfected in HEK293T cells at 24 hrs by dual luciferase reporter gene-based minireplicon assay | Influenza A virus | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA3796336 | U | Ratio of IC50 for Influenza A virus PR/8/34 6His-tagged PA (239 to 716 residues) interaction with GST-tagged PB1 (1 to 25 residues) to EC50 for Influenza A virus PR/8/34 infected in MDCK cells | Influenza A virus | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA3796337 | T | Selectivity index, ratio of CC50 for MDCK cells to EC50 for Influenza A virus PR/8/34 infected in MDCK cells | 18 | cell-based format | Scientific Literature | |||
| 9. | ALA4275225 | B | Inhibition of Influenza A virus A/PR/8/34 (H1N1) 6His-tagged PA (239 to 716 residues)/GST-tagged PB1 (1 to 25 residues) interaction expressed in Escherichia coli incubated overnight by ELISA | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 17 | assay format | Scientific Literature | ||
| 10. | ALA4275226 | F | Antiviral activity against Influenza A virus A/PR/8/34 (H1N1) infected in MDCK cells measured after 2 days by plaque reduction assay | Influenza A virus | 19 | organism-based format | Scientific Literature | ||
| 11. | ALA4275227 | A | Cytotoxicity against MDCK cells assessed as decrease in cell viability after 48 hrs by MTT assay | Canis lupus familiaris | 19 | cell-based format | Scientific Literature | ||
| 12. | ALA4275228 | A | Cytotoxicity against HEK293T cells assessed as decrease in cell viability after 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 13. | ALA4275229 | B | Inhibition of Influenza A virus A/PR/8/34 (H1N1) PA-PB1 interaction expressed in HEK293T cells assessed as decrease in RNA polymerase activity incubated for 24 hrs by minireplicon based luciferase reporter gene assay | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 9 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!