# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3796338 | Binding | Inhibition of recombinant human Lp-PLA2 at 100 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Homo sapiens | 25 | ALA3792272 | single protein format | Scientific Literature | |
2. | ALA3796339 | Binding | Inhibition of recombinant human Lp-PLA2 at 10 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Homo sapiens | 24 | ALA3792272 | single protein format | Scientific Literature | |
3. | ALA3796340 | Binding | Inhibition of recombinant human Lp-PLA2 using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Homo sapiens | 21 | ALA3792272 | single protein format | Scientific Literature | |
4. | ALA3796341 | ADME | Intrinsic clearance in human liver S9 fraction at 0.1 uM | Homo sapiens | 18 | ALA3792272 | subcellular format | Scientific Literature | |
5. | ALA3796342 | ADME | Intrinsic clearance in Wistar rat liver S9 fraction at 0.1 uM | Rattus norvegicus | 18 | ALA3792272 | subcellular format | Scientific Literature | |
6. | ALA3796343 | ADME | Apparent permeability from apical to basolateral side in human Caco2 cells incubated for 95 mins by LC-MS/MS analysis | Homo sapiens | 11 | ALA3792272 | cell-based format | Scientific Literature | |
7. | ALA3796344 | ADME | Efflux ratio of apparent permeability in human Caco2 cells incubated for 95 mins by LC-MS/MS analysis | Homo sapiens | 11 | ALA3792272 | cell-based format | Scientific Literature | |
8. | ALA3796345 | Binding | Inhibition of Lp-PLA2 in human plasma at 10 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Homo sapiens | 9 | ALA3792272 | cell-free format | Scientific Literature | |
9. | ALA3796346 | Binding | Inhibition of Lp-PLA2 in human plasma at 1 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Homo sapiens | 9 | ALA3792272 | cell-free format | Scientific Literature | |
10. | ALA3796347 | Binding | Inhibition of Lp-PLA2 in rat plasma at 100 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Rattus norvegicus | 9 | ALA3792272 | cell-free format | Scientific Literature | |
11. | ALA3796348 | Binding | Inhibition of Lp-PLA2 in rat plasma at 10 nM using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis | Rattus norvegicus | 9 | ALA3792272 | cell-free format | Scientific Literature | |
12. | ALA3796349 | ADME | AUC (0 to 24 hrs) in Sprague-Dawley rat at 5 mg/kg, iv after 5 mins to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3792272 | organism-based format | Scientific Literature | |
13. | ALA3796351 | ADME | Half life in Sprague-Dawley rat at 5 mg/kg, iv after 5 mins to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3792272 | organism-based format | Scientific Literature | |
14. | ALA3796353 | ADME | Clearance in Sprague-Dawley rat at 5 mg/kg, iv after 5 mins to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3792272 | organism-based format | Scientific Literature | |
15. | ALA3796355 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv after 5 mins to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3792272 | organism-based format | Scientific Literature | |
16. | ALA3796357 | ADME | AUC (0 to 24 hrs) in Sprague-Dawley rat at 50 mg/kg, po after 0.5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3792272 | organism-based format | Scientific Literature | |
17. | ALA3796358 | ADME | Cmax in Sprague-Dawley rat at 50 mg/kg, po after 0.5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3792272 | organism-based format | Scientific Literature | |
18. | ALA3796359 | ADME | Tmax in Sprague-Dawley rat at 50 mg/kg, po after 0.5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3792272 | organism-based format | Scientific Literature | |
19. | ALA3796360 | ADME | Oral bioavailability in Sprague-Dawley rat at 50 mg/kg after 0.5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3792272 | organism-based format | Scientific Literature | |
20. | ALA3796361 | Functional | In vivo inhibition of Lp-PLA2 in Sprague-Dawley rat serum at 3 to 25 mg/kg, po administered through gavage using 2-thio-PAF as substrate after 1 to 24 hrs by plate reader analysis | Rattus norvegicus | 1 | ALA3792272 | organism-based format | Scientific Literature |