| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3794747 | B | Inhibition of FLT3 autophosphorylation at Tyr-596 in human MV4-11 cells after 1.5 hrs by Western blot analysis | Homo sapiens | 1 | ALA3792292 | cell-based format | Scientific Literature | |
| 2. | ALA3794748 | A | Growth inhibition of human WI38 cells after 48 hrs by CCK8 assay | Homo sapiens | 2 | ALA3792292 | cell-based format | Scientific Literature | |
| 3. | ALA3794749 | F | Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 48 hrs by CCK8 assay | Homo sapiens | 2 | ALA3792292 | cell-based format | Scientific Literature | |
| 4. | ALA3794750 | B | Inhibition of human N-terminal GST-tagged FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system using fluorescence labelled srctide as substrate by mobility shift assay in presence of ATP | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 5. | ALA3794751 | F | Induction of apoptosis in human MV4-11 cells at 0.17 to 17 uM after 48 hrs by annexin V/propidium iodide staining based flow cytometry | Homo sapiens | 1 | ALA3792292 | cell-based format | Scientific Literature | |
| 6. | ALA3794752 | B | Inhibition of human N-terminal GST-tagged FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system using 5-FAM-peptide 2 as substrate after 2 hrs by electrophoretic mobility shift assay in presence of ATP | Homo sapiens | 27 | ALA3792292 | assay format | Scientific Literature | |
| 7. | ALA3794753 | A | Inhibition of human CYP2C9 at 10 uM relative to control | Homo sapiens | 1 | ALA3792292 | single protein format | Scientific Literature | |
| 8. | ALA3794754 | A | Inhibition of human recombinant CYP1A2 using CEC as substrate at 10 uM after 30 mins by fluorimetry relative to control | Homo sapiens | 1 | ALA3792292 | single protein format | Scientific Literature | |
| 9. | ALA3794755 | A | Inhibition of human CYP2C19 at 10 uM relative to control | Homo sapiens | 1 | ALA3792292 | single protein format | Scientific Literature | |
| 10. | ALA3794756 | A | Inhibition of human CYP2D6 at 10 uM relative to control | Homo sapiens | 1 | ALA3792292 | single protein format | Scientific Literature | |
| 11. | ALA3794757 | A | Inhibition of human recombinant CYP3A4 at 10 uM by fluorimetry relative to control | Homo sapiens | 1 | ALA3792292 | single protein format | Scientific Literature | |
| 12. | ALA3794758 | P | Aqueous solubility in pH 7.4 PBS buffer at 200 uM after 24 hrs by UV-visible HPLC based shake flask method | 1 | ALA3792292 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA3794759 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 1 hr | Homo sapiens | 1 | ALA3792292 | tissue-based format | Scientific Literature | |
| 14. | ALA3794760 | A | Permeability from apical to basolateral side in human Caco2 cells at 10 uM after 60 mins by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA3792292 | cell-based format | Scientific Literature | |
| 15. | ALA3794761 | B | Inhibition of full length human N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using fluorescence labelled ABLtide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 16. | ALA3794762 | B | Inhibition of full length human N-terminal GST-tagged CSK (1 to 450 residues) expressed in baculovirus expression system using fluorescence labelled srctide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 17. | ALA3794763 | B | Inhibition of human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using fluorescence labelled srctide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 18. | ALA3794764 | B | Inhibition of human N-terminal GST-tagged EPHA2 cytoplasmic domain (572 to 976 residues) expressed in baculovirus expression system using fluorescence labelled Blk/Lyntide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 19. | ALA3794765 | B | Inhibition of human N-terminal GST-tagged EPHB4 cytoplasmic domain (577 to 987 residues) expressed in baculovirus expression system using fluorescence labelled Blk/Lyntide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature | |
| 20. | ALA3794766 | B | Inhibition of human N-terminal GST-tagged FGFR1 cytoplasmic domain (398 to 822 residues) expressed in baculovirus expression system using fluorescence labelled CSKtide as substrate at 50 times IC50 by electrophoretic mobility shift assay relative to control | Homo sapiens | 3 | ALA3792292 | assay format | Scientific Literature |
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