# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3803201 | Binding | Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluorescence plate reader | Homo sapiens | 12 | ALA3797041 | assay format | Scientific Literature | |
2. | ALA3803202 | Binding | Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis | Homo sapiens | 9 | ALA3797041 | cell-based format | Scientific Literature | |
3. | ALA3803203 | ADME | Inhibition of human CYP1A2 expressed in Escherichia coli DH5alpha | Homo sapiens | 9 | ALA3797041 | assay format | Scientific Literature | |
4. | ALA3803204 | ADME | Extraction ratio in rat liver microsomes | Rattus norvegicus | 1 | ALA3797041 | tissue-based format | Scientific Literature | |
5. | ALA3803205 | ADME | Extraction ratio in human liver microsomes at 1 uM | Rattus norvegicus | 5 | ALA3797041 | tissue-based format | Scientific Literature | |
6. | ALA3803206 | ADME | Extraction ratio in human hepatocytes | Rattus norvegicus | 1 | ALA3797041 | cell-based format | Scientific Literature | |
7. | ALA3803207 | ADME | AUC in Sprague-Dawley rat at 2.9 mg/kg, po | Rattus norvegicus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
8. | ALA3803208 | ADME | Half life in Sprague-Dawley rat at 2.9 mg/kg, po | Rattus norvegicus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
9. | ALA3803209 | ADME | Clearance in Sprague-Dawley rat at 2.9 mg/kg, po | Rattus norvegicus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
10. | ALA3803210 | ADME | Volume of distribution in Sprague-Dawley rat at 2.9 mg/kg, po | Rattus norvegicus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
11. | ALA3803211 | ADME | Oral bioavailability in Sprague-Dawley rat at 2.9 mg/kg | Rattus norvegicus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
12. | ALA3803212 | Functional | Antiobesity in diet-induced obese mouse model assessed as decrease in body weight at 30 mg/kg, po qd for 7 days relative to control | Mus musculus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
13. | ALA3803213 | Toxicity | Toxicity in diet-induced obese mouse model assessed as effect on food intake at 30 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA3797041 | organism-based format | Scientific Literature | |
14. | ALA3803214 | Toxicity | Toxicity in diet-induced obese mouse model assessed as effect on activity levels at 30 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA3797041 | organism-based format | Scientific Literature |