# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3802538 | F | Cytoprotective activity in endoplasmic reticulum stressed rat INS-1 cells assessed as rescue from tunicamycin-mediated reduction in cell survival after 72 hrs by CellTiter-Glo assay | Rattus norvegicus | 42 | ALA3797120 | cell-based format | Scientific Literature | |
2. | ALA3802539 | F | Cytoprotective activity in endoplasmic reticulum stressed rat INS-1 cells assessed as rescue from tunicamycin-mediated reduction in cell viability at 10 uM after 72 hrs by CellTiter-Glo assay relative to control | Rattus norvegicus | 21 | ALA3797120 | cell-based format | Scientific Literature | |
3. | ALA3802746 | F | Inhibition of endoplasmic reticulum stress-mediated upregulation of CHOP protein expression in tunicamycin-treated rat INS-1 cells at 20 uM after 2 to 8 hrs by Western blot method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
4. | ALA3802747 | F | Inhibition of endoplasmic reticulum stress-mediated upregulation of CHOP mRNA expression in tunicamycin-treated rat INS-1 cells at 10 uM by qRT-PCR method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
5. | ALA3802748 | F | Inhibition of endoplasmic reticulum stress-mediated upregulation of CHOP mRNA expression in tunicamycin-treated rat INS-1 cells after 2 to 8 hrs by qRT-PCR method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
6. | ALA3802749 | A | Effect on basal CHOP mRNA expression in rat INS-1 cells at 10 uM after 2 to 8 hrs by qRT-PCR method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
7. | ALA3802753 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in tunicamycin-treated C57BL/6 mouse primary pancreatic islet beta cells assessed as DNA fragmentation at 10 uM after 24 hrs by TUNEL assay (Rvb = 40.4%) | Mus musculus | 1 | ALA3797120 | assay format | Scientific Literature | |
8. | ALA3802754 | F | Cytoprotective activity against endoplasmic reticulum stress-induced cell death in tunicamycin-treated CHOP knock out C57BL/6 mouse primary pancreatic islet beta cells assessed as DNA fragmentation at 10 uM after 24 hrs by TUNEL assay (Rvb = 18.7%) | Mus musculus | 1 | ALA3797120 | assay format | Scientific Literature | |
9. | ALA3802755 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in tunicamycin-treated rat INS-1 cells assessed as DNA fragmentation at 20 uM after 24 hrs by TUNEL assay (Rvb = 15%) | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
10. | ALA3802756 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as suppression of tunicamycin-induced PARP cleavage at 20 uM after 2 to 24 hrs by Western blot method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
11. | ALA3802757 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as suppression of tunicamycin-induced caspase-3 cleavage at 20 uM after 2 to 24 hrs by Western blot method | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
12. | ALA3802758 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as decrease in brefeldin A-induced cell death by measuring cell viability at 5 to 20 uM after 72 hrs by CellTiter-Glo assay | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
13. | ALA3802759 | A | Effect on growth rate of rat INS-1 cells at 2.5 to 10 uM after 72 hrs by CellTiter-Glo assay relative to control | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
14. | ALA3802760 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as decrease in sodium palmitate-induced cell death by measuring cell viability at 2.5 to 20 uM after 72 hrs by CellTiter-Glo assay | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
15. | ALA3802761 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in mouse BetaTC6 cells assessed as decrease in tunicamycin-induced cell death by measuring cell viability at 2.5 to 20 uM after 72 hrs by CellTiter-Glo assay | Mus musculus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
16. | ALA3802762 | B | Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as restoration of tunicamycin-mediated reduction of 20 mM glucose-stimulated insulin secretion preincubated for 24 hrs followed by glucose addition and subsequent incubation for 45 mins by ELISA | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
17. | ALA3802763 | A | Effect on 20 mM glucose-stimulated insulin secretion in rat INS-1 cells preincubated for 24 hrs followed by glucose addition and subsequent incubation for 45 mins by ELISA | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
18. | ALA3802764 | A | Effect on 2.5 mM glucose-stimulated insulin secretion in rat INS-1 cells preincubated for 24 hrs followed by glucose addition and subsequent incubation for 45 mins by ELISA | Rattus norvegicus | 1 | ALA3797120 | cell-based format | Scientific Literature | |
19. | ALA3802765 | F | Antidiabetic activity in streptozotocin-induced diabetic C57BL/6 mouse model assessed as decrease in blood glucose level at 20 mg/kg, ip administered for 5 consecutive days with streptozotocin followed by 2 more weeks compound addition without streptozotocin measured every 3 day of compound dosing by glucometer relative to control | Mus musculus | 1 | ALA3797120 | organism-based format | Scientific Literature | |
20. | ALA3802766 | F | Antidiabetic activity in streptozotocin-induced diabetic C57BL/6 mouse model assessed as total pancreatic islet area at 20 mg/kg, ip administered for 5 consecutive days with streptozotocin followed by 2 more weeks compound addition without streptozotocin measured post last dose by DAPI staining-based confocal microscopy (Rvb = 21.3 +/- 4.4%) | Mus musculus | 1 | ALA3797120 | organism-based format | Scientific Literature |