# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3803472 | F | Agonist activity at human recombinant S1PR3 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis | Homo sapiens | 60 | ALA3797028 | cell-based format | Scientific Literature | |
2. | ALA3803473 | F | Agonist activity at human recombinant S1PR1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis | Homo sapiens | 65 | ALA3797028 | cell-based format | Scientific Literature | |
3. | ALA3803474 | F | Change in circulating lymphocyte count in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 24 hrs relative to control | Rattus norvegicus | 8 | ALA3797028 | organism-based format | Scientific Literature | |
4. | ALA3803475 | F | Change in circulating lymphocyte count in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 6 hrs relative to control | Rattus norvegicus | 8 | ALA3797028 | organism-based format | Scientific Literature | |
5. | ALA3803476 | F | Change in circulating lymphocyte count in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 3 hrs relative to control | Rattus norvegicus | 8 | ALA3797028 | organism-based format | Scientific Literature | |
6. | ALA3803477 | A | Apparent oral clearance in Wistar rat plasma at 1 to 10 mg/kg administered through gavage by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3797028 | organism-based format | Scientific Literature | |
7. | ALA3803478 | B | Selectivity ratio of EC50 for human recombinant S1PR3 expressed in CHO cell membranes to EC50 for human recombinant S1PR1 expressed in CHO cell membranes | Homo sapiens | 59 | ALA3797028 | cell-based format | Scientific Literature | |
8. | ALA3803479 | A | Apparent intrinsic clearance in Wistar rat liver microsomes at 1 uM after 2.5 to 15 mins by LC-MS/MS analysis in presence of NADPH | Rattus norvegicus | 9 | ALA3797028 | tissue-based format | Scientific Literature | |
9. | ALA3803480 | P | Distribution coefficient, log D between 1-octonol and phosphate buffer at pH 7 | 9 | ALA3797028 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3803481 | A | Fraction unbound in Wistar rat liver microsomes incubated for 6 hrs by LC-MS/MS based equilibrium dialysis method | Rattus norvegicus | 9 | ALA3797028 | tissue-based format | Scientific Literature | |
11. | ALA3803482 | A | Fraction unbound in Wistar rat plasma incubated for 6 hrs by LC-MS/MS based equilibrium dialysis method | Rattus norvegicus | 9 | ALA3797028 | cell-free format | Scientific Literature | |
12. | ALA3803483 | A | Unbound fraction corrected apparent intrinsic clearance in Wistar rat liver microsomes at 1 uM after 2.5 to 15 mins by LC-MS/MS analysis in presence of NADPH | Rattus norvegicus | 9 | ALA3797028 | tissue-based format | Scientific Literature | |
13. | ALA3803485 | F | Change in circulating lymphocyte count in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 96 hrs relative to control | Rattus norvegicus | 1 | ALA3797028 | organism-based format | Scientific Literature | |
14. | ALA3803486 | A | Plasma concentration in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 3 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3797028 | organism-based format | Scientific Literature | |
15. | ALA3803487 | A | Plasma concentration in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3797028 | organism-based format | Scientific Literature | |
16. | ALA3803488 | A | Plasma concentration in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3797028 | organism-based format | Scientific Literature | |
17. | ALA3803489 | A | Plasma concentration in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 72 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3797028 | organism-based format | Scientific Literature | |
18. | ALA3803490 | A | Plasma concentration in Wistar rat at 10 mg/kg administered as single dose through oral gavage after 96 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3797028 | organism-based format | Scientific Literature | |
19. | ALA3803491 | A | Intrinsic clearance in Wistar rat at 1 to 10 mg/kg administered through gavage by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3797028 | organism-based format | Scientific Literature | |
20. | ALA3803493 | B | Agonist activity at S1PR2 (unknown origin) | Homo sapiens | 1 | ALA3797028 | single protein format | Scientific Literature |