# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3801515 | B | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
2. | ALA3801516 | B | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 27 | ALA3797125 | cell-based format | Scientific Literature | |
3. | ALA3801517 | B | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
4. | ALA3801519 | B | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
5. | ALA3801520 | B | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 32 | ALA3797125 | cell-based format | Scientific Literature | |
6. | ALA3801521 | B | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
7. | ALA3801526 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in MDCK cells expressing human MDR1 | Canis lupus familiaris | 44 | ALA3797125 | cell-based format | Scientific Literature | |
8. | ALA3801537 | B | Selectivity ratio of EC50 for human GluA2 AMPAR flip isomer to EC50 for GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells | Homo sapiens | 1 | ALA3797125 | cell-based format | Scientific Literature | |
9. | ALA3871160 | B | Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flux measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay | Homo sapiens | 15 | ALA3870360 | cell-based format | Scientific Literature | |
10. | ALA3871161 | B | Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flux at 125 uM measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay relative to glutamate | Homo sapiens | 15 | ALA3870360 | cell-based format | Scientific Literature | |
11. | ALA3871162 | A | Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay | Homo sapiens | 11 | ALA3870360 | single protein format | Scientific Literature | |
12. | ALA3871163 | A | Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux at 125 uM measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay relative to glutamate | Homo sapiens | 15 | ALA3870360 | single protein format | Scientific Literature | |
13. | ALA3871164 | A | Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay | Homo sapiens | 11 | ALA3870360 | single protein format | Scientific Literature | |
14. | ALA3871165 | A | Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux at 125 uM measured at time interval of 5 mins in presence of saturating glycine by calcium dye-based fluorescence assay relative to glutamate | Homo sapiens | 15 | ALA3870360 | single protein format | Scientific Literature |