# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3801515 | Binding | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
2. | ALA3801516 | Binding | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 27 | ALA3797125 | cell-based format | Scientific Literature | |
3. | ALA3801517 | Binding | Positive allosteric modulation of GluN1/GluN2A NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
4. | ALA3801518 | Binding | Positive allosteric modulation of GluN1/GluN2B NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 4 | ALA3797125 | cell-based format | Scientific Literature | |
5. | ALA3801519 | Binding | Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
6. | ALA3801520 | Binding | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 32 | ALA3797125 | cell-based format | Scientific Literature | |
7. | ALA3801521 | Binding | Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells at 125 uM measured every 5 mins by BD calcium indicator dye based-fluorescence analysis in presence of glutamate | Homo sapiens | 46 | ALA3797125 | cell-based format | Scientific Literature | |
8. | ALA3801522 | Binding | Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | ALA3797125 | cell-based format | Scientific Literature | |
9. | ALA3801523 | Binding | Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | ALA3797125 | cell-based format | Scientific Literature | |
10. | ALA3801524 | Binding | Positive allosteric modulation of GluN1/GluN2D NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | ALA3797125 | cell-based format | Scientific Literature | |
11. | ALA3801525 | Binding | Positive allosteric modulation of GluN1/GluN2D NMDAR (unknown origin) expressed in Dox-inducible cells at 125 uM by BD calcium indicator dye based-fluorescence analysis in presence of glutamate/glycine | Homo sapiens | 1 | ALA3797125 | cell-based format | Scientific Literature | |
12. | ALA3801526 | ADME | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in MDCK cells expressing human MDR1 | Canis lupus familiaris | 44 | ALA3797125 | cell-based format | Scientific Literature | |
13. | ALA3801527 | ADME | Plasma protein binding in mouse | Mus musculus | 1 | ALA3797125 | cell-free format | Scientific Literature | |
14. | ALA3801528 | ADME | Protein binding in mouse brain | Mus musculus | 1 | ALA3797125 | tissue-based format | Scientific Literature | |
15. | ALA3801529 | ADME | Blood clearance in mouse at 0.3 mg/kg, iv | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature | |
16. | ALA3801530 | ADME | Half life in mouse at 0.3 mg/kg, iv | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature | |
17. | ALA3801531 | ADME | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature | |
18. | ALA3801532 | ADME | Fraction unbound in mouse brain at 10 mg/kg, po measured at 1 hr | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature | |
19. | ALA3801533 | ADME | Fraction unbound in mouse plasma at 10 mg/kg, po measured at 1 hr | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature | |
20. | ALA3801534 | ADME | Ratio of fraction unbound in mouse brain to plasma at 10 mg/kg, po measured at 1 hr | Mus musculus | 1 | ALA3797125 | organism-based format | Scientific Literature |