| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3801549 | A | Inhibition of CYP3A4 in human liver microsomes using testosterone and midazolam as substrate preincubated for 30 mins followed substrate addition by LC-MS/MS analysis | Homo sapiens | 14 | ALA3797133 | tissue-based format | Scientific Literature | |
| 2. | ALA3801550 | B | Inhibition of recombinant human BACE1 preincubated for 30 mins followed QSY7EISEVNLDAEFC-Eu-amide substrate addition measured after 90 mins by FRET assay | Homo sapiens | 20 | ALA3797133 | single protein format | Scientific Literature | |
| 3. | ALA3801551 | B | Inhibition of BACE1 in human HEK293 cells transfected with human APP Swe/Lon mutations assessed as amyloid beta 40 level after 4 hrs by electrochemiluminescence-based sandwich ELISA | Homo sapiens | 18 | ALA3797133 | cell-based format | Scientific Literature | |
| 4. | ALA3801552 | B | Selectivity ratio, ratio for inhibition for human cathepsin D to inhibition for human BACE1 | Homo sapiens | 20 | ALA3797133 | assay format | Scientific Literature | |
| 5. | ALA4270026 | B | Inhibition of recombinant human BACE1 expressed in HEK293 cells | Homo sapiens | 20 | ALA4266039 | cell-based format | Scientific Literature | |
| 6. | ALA4270027 | A | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate/NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 20 | ALA4266039 | microsome format | Scientific Literature | |
| 7. | ALA4270030 | F | Anti-alzheimer activity in rat assessed as reduction in amyloid beta40 levels in cerebrospinal fluid at 30 mg/kg, po relative to control | Rattus norvegicus | 3 | ALA4266039 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!