| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3803623 | B | Inhibition of recombinant Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate preincubated for 90 mins followed by BML-KI176 addition measured after 45 mins by fluorescence assay | Schistosoma mansoni | 41 | assay format | Scientific Literature | ||
| 2. | ALA3803862 | B | Inhibition of recombinant human HDAC8 using Fluor de Lys as substrate preincubated for 90 mins followed by BML-KI176 addition measured after 45 mins by fluorescence assay | Homo sapiens | 41 | single protein format | Scientific Literature | ||
| 3. | ALA3803863 | B | Inhibition of recombinant human HDAC1 using Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition measured after 20 mins by fluorescence assay | Homo sapiens | 37 | single protein format | Scientific Literature | ||
| 4. | ALA3803864 | B | Inhibition of recombinant human HDAC6 using Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition measured after 20 mins by fluorescence assay | Homo sapiens | 40 | single protein format | Scientific Literature | ||
| 5. | ALA3801375 | A | Cytotoxicity against HEK293 cells assessed as cell viability at 50 uM after 24 hrs by Alamar Blue assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 6. | ALA4014727 | B | Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assay | Schistosoma mansoni | 168 | single protein format | Scientific Literature | ||
| 7. | ALA4027158 | F | Cytotoxicity against human BE(2)-C cells assessed as reduction in clonogenic growth at 10 uM administered for 96 hrs followed by 6 days growth time in absence of compound treatment by crystal violet-based assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4027159 | A | Inhibition of HDAC1 in human BE(2)-C cells assessed as effect on histone H3 acetylation at 10 uM after 6 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4027160 | A | Inhibition of HDAC6 in human BE(2)-C cells assessed as induction of increase in alpha tubulin acetylation at 10 uM after 6 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4027161 | B | Inhibition of HDAC8 in human BE(2)-C cells assessed as induction of increase in SMC3 acetylation at 10 uM after 6 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4027162 | A | Cytotoxicity against HEK293 cells assessed as cell viability at 50 uM after 24 hrs by Alamar blue assay relative to control | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 12. | ALA4027165 | U | Selectivity index, ratio of IC50 for recombinant human full length HDAC6 to IC50 for recombinant human full length C-terminal His-tagged HDAC8 | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 13. | ALA4027167 | A | Inhibition of recombinant human full length HDAC6 expressed in fall armyworm Sf9 cells using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 14. | ALA4027170 | U | Selectivity index, ratio of IC50 for recombinant human full length C-terminal FLAG-tagged HDAC1 to IC50 for recombinant human full length C-terminal His-tagged HDAC8 | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 15. | ALA4027171 | F | Induction of outgrowth of neurofilament positive neutrite-like structures in human BE(2)-C cells at 10 uM after 6 days by DAPI-staining based microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4027172 | A | Inhibition of recombinant human full length HDAC6 expressed in fall armyworm Sf9 cells at 5 uM using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4027174 | A | Inhibition of recombinant human full length HDAC6 expressed in fall armyworm Sf9 cells at 25 uM using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4027176 | A | Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC1 expressed in fall armyworm Sf9 cells at 5 uM using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4027177 | A | Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC1 expressed in fall armyworm Sf9 cells using fluorogenic ZMAL as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 20. | ALA4027180 | B | Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in Escherichia coli BL21(DE3) using fluor de Lys(R) as substrate after 90 mins by fluorimetric analysis | Homo sapiens | 31 | assay format | Scientific Literature |
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