# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3801620 | Binding | Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis | Homo sapiens | 34 | ALA3797060 | cell-based format | Scientific Literature | |
2. | ALA3801622 | Binding | Selectivity ratio of Ki for human alpha1A adrenergic receptor to Ki for human alpha1D adrenergic receptor | Homo sapiens | 4 | ALA3797060 | assay format | Scientific Literature | |
3. | ALA3801623 | Binding | Selectivity ratio of Ki for human alpha1B adrenergic receptor to Ki for human alpha1D adrenergic receptor | Homo sapiens | 4 | ALA3797060 | assay format | Scientific Literature | |
4. | ALA3801624 | Binding | Inhibition of human ERG channel expressed in CHO cells assessed as peak tail current at 10 uM incubated for 5 mins by patch-clamp assay | Homo sapiens | 15 | ALA3797060 | cell-based format | Scientific Literature | |
5. | ALA3801628 | ADME | Volume of distribution at steady state in rat at 0.1 mg/kg, iv administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
6. | ALA3801629 | ADME | Total clearance in rat at 0.1 mg/kg, iv administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
7. | ALA3801630 | ADME | Cmax in rat at 1 mg/kg, po administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
8. | ALA3801631 | ADME | AUC in rat at 1 mg/kg, po administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
9. | ALA3801632 | ADME | Mean residence time in rat at 1 mg/kg, po administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
10. | ALA3801633 | ADME | Oral bioavailability in rat at 1 mg/kg administered via cassette dosing by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA3797060 | organism-based format | Scientific Literature | |
11. | ALA3801634 | Functional | Inhibition of (R)-(-)-phenylephrine hydrochloride-induced contractions in Wistar rat bladder with outlet obstruction treated every 30 minutes post (R)-(-)-phenylephrine hydrochloride challenge | Rattus norvegicus | 2 | ALA3797060 | assay format | Scientific Literature | |
12. | ALA3801635 | Functional | Inhibition of nonvoiding contractions during urinary storage phase in iv dosed Wistar rat with bladder outlet obstruction after 10 mins by cystometrogram | Rattus norvegicus | 2 | ALA3797060 | organism-based format | Scientific Literature | |
13. | ALA3801636 | Functional | Reduction of urinary frequency in po dosed Sprague-Dawley rat with cyclophosphamide-induced cystitis assessed as increased voiding intervals administered at voiding intervals less <7.2 mins measured after 5 to 35 mins by cystometrogram | Rattus norvegicus | 2 | ALA3797060 | organism-based format | Scientific Literature |