# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3802882 | Binding | Inhibition of PI3Kdelta in human JeKo1 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 1 hr | Homo sapiens | 1 | ALA3797054 | cell-based format | Scientific Literature | |
2. | ALA3802883 | Binding | Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by luminescence assay | Homo sapiens | 8 | ALA3797054 | single protein format | Scientific Literature | |
3. | ALA3802884 | Binding | Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by luminescence assay | Homo sapiens | 8 | ALA3797054 | single protein format | Scientific Literature | |
4. | ALA3802885 | Binding | Inhibition of human recombinant PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by luminescence assay | Homo sapiens | 8 | ALA3797054 | single protein format | Scientific Literature | |
5. | ALA3802886 | Binding | Inhibition of human recombinant PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by luminescence assay | Homo sapiens | 8 | ALA3797054 | single protein format | Scientific Literature | |
6. | ALA3802887 | Binding | Inhibition of PI3Kalpha mutant in human BT474 cells assessed as inhibition of AKT phosphorylation at Thr-308 residue after 2 hrs by ELISA | Homo sapiens | 17 | ALA3797054 | cell-based format | Scientific Literature | |
7. | ALA3802888 | Binding | Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate reader analysis | Homo sapiens | 17 | ALA3797054 | cell-based format | Scientific Literature | |
8. | ALA3802890 | Physicochemical | Lipophilicity, log D of compound at pH 7.4 | 16 | ALA3797054 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3802891 | ADME | Intrinsic clearance in human hepatocytes assessed per million cells | Homo sapiens | 15 | ALA3797054 | cell-based format | Scientific Literature | |
10. | ALA3802892 | Physicochemical | Solubility in pH 7.4 phosphate buffer using solid compound | 12 | ALA3797054 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3802893 | ADME | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM for 2 hrs by LC-MS/MS analysis | Homo sapiens | 11 | ALA3797054 | cell-based format | Scientific Literature | |
12. | ALA3802894 | ADME | AUC in hairy mouse at 30 umol/kg, po | Mus musculus | 8 | ALA3797054 | organism-based format | Scientific Literature | |
13. | ALA3802895 | Physicochemical | Aqueous solubility of crystalline compound in fasted simulated intestinal fluid | 1 | ALA3797054 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3802896 | Physicochemical | Aqueous solubility of crystalline compound in pH 6.5 buffer | 1 | ALA3797054 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3802897 | Binding | Inhibition of human ERG | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature | |
16. | ALA3802898 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature | |
17. | ALA3802899 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature | |
18. | ALA3802900 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature | |
19. | ALA3802901 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature | |
20. | ALA3802902 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA3797054 | single protein format | Scientific Literature |