| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3803186 | F | Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 2. | ALA3803187 | F | Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization relative to glutamate | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA3804545 | F | Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 4. | ALA3804546 | F | Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization relative to glutamate | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 5. | ALA3804547 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 6. | ALA3804548 | A | Clearance in rat liver microsomes | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
| 7. | ALA3804549 | A | Fraction unbound in human plasma | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 8. | ALA3804550 | A | Fraction unbound in rat plasma | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 9. | ALA3804551 | A | Fraction unbound in rat brain homogenate | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
| 10. | ALA3804552 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 11. | ALA3804553 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 12. | ALA3804554 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA3804555 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA3804556 | A | Plasma concentration in rat at 0.25 mg/kg, iv measured at the last time point | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA3804557 | A | Drug uptake in rat brain at 0.25 mg/kg, iv measured at the last time point | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA3804558 | A | Ratio of drug level in brain to plasma in rat at 0.25 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA3804559 | B | Positive allosteric modulation of human mGlu1 receptor assessed as glutamate efficacy at 10 uM (Rvb = 95.2 +/- 3.5 %) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA3804560 | B | Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA3804561 | B | Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA3804562 | B | Positive allosteric modulation of human mGlu1 receptor assessed as potentiation of glutamate-induced effect at 10 uM relative to control | Homo sapiens | 3 | single protein format | Scientific Literature |
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