| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3801492 | Binding | Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by substrate addition measured after 25 mins by SAC TAMRA tracer-based fluorescence polarization assay | Homo sapiens | 16 | ALA3797074 | assay format | Scientific Literature | |
| 2. | ALA3801493 | Binding | Inhibition of recombinant human C-terminal His6-tagged soluble COMT transfected in Escherichia coli BL21-Gold (DE3) using SAM/dopamine as substrate preincubated for 2 hrs followed by substrate addition measured after 25 mins by SAC TAMRA tracer-based fluorescence polarization assay | Homo sapiens | 9 | ALA3797074 | assay format | Scientific Literature | |
| 3. | ALA3801494 | Binding | Inhibition of recombinant rat C-terminal His10-tagged MB-COMT transfected in Escherichia coli BL21-CodonPlus(DE3)-RIPL using SAM/dopamine as substrate preincubated for 2 hrs followed by substrate addition measured after 25 mins by SAC TAMRA tracer-based fluorescence polarization assay | Rattus norvegicus | 8 | ALA3797074 | assay format | Scientific Literature | |
| 4. | ALA3801495 | ADME | Intrinsic clearance in human hepatocytes | Homo sapiens | 3 | ALA3797074 | cell-based format | Scientific Literature | |
| 5. | ALA3801496 | ADME | Intrinsic clearance in rat hepatocytes | Rattus norvegicus | 3 | ALA3797074 | cell-based format | Scientific Literature | |
| 6. | ALA3801497 | ADME | Plasma clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA3797074 | organism-based format | Scientific Literature | |
| 7. | ALA3801498 | Functional | In vivo inhibition of MB-COMT in ip dosed rat assessed as increase in dihydroxyphenylacetic acid level in cerebrospinal fluid after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 8. | ALA3801499 | Functional | In vivo inhibition of MB-COMT in ip dosed rat assessed as decrease in homovanillic acid level in cerebrospinal fluid after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 9. | ALA3801500 | ADME | Plasma concentration in rat at 30 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 10. | ALA3801501 | ADME | Plasma concentration in rat at 100 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 11. | ALA3801502 | ADME | Drug uptake in rat cerebrospinal fluid at 30 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 12. | ALA3801503 | ADME | Drug uptake in rat cerebrospinal fluid at 100 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 13. | ALA3801504 | ADME | Volume of distribution in rat at 0.5 mg/kg, iv | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature | |
| 14. | ALA3801505 | ADME | Half life in rat at 0.5 mg/kg, iv | Rattus norvegicus | 1 | ALA3797074 | organism-based format | Scientific Literature |
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