# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3807013 | Functional | Neuroprotective activity in hypoxic-ischemia-induced neonatal Sprague-Dawley rat brain assessed as reduction brain infarction at 10 mg/kg, ip administered 15 mins prior to examination by microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
2. | ALA3807014 | Binding | Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay | Homo sapiens | 22 | ALA3804780 | assay format | Scientific Literature | |
3. | ALA3807015 | Binding | Inhibition of His-tagged human recombinant caspase 3 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay | Homo sapiens | 22 | ALA3804780 | assay format | Scientific Literature | |
4. | ALA3807016 | Functional | Neuroprotective activity in hypoxic-ischemic neonatal Sprague-Dawley rat brain assessed as inhibition of elevated caspase 3 expression levels at 30 mg/kg, ip administered 15 mins prior to examination measured after 48 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
5. | ALA3807017 | Functional | Neuroprotective activity in hypoxic-ischemia-induced neonatal Sprague-Dawley rat brain assessed as reduction brain infarction at 20 mg/kg, ip administered 15 mins prior to examination by microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
6. | ALA3807088 | Functional | Neuroprotective activity in hypoxic-ischemic-induced neonatal Sprague-Dawley rat brain assessed as reduction brain infarction at 30 mg/kg, ip administered 15 mins prior to examination by microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
7. | ALA3807090 | Functional | Neuroprotective activity in hypoxic-ischemic neonatal Sprague-Dawley rat brain assessed as distribution of neurons in cortex at 30 mg/kg, ip administered 15 mins prior to examination measured after 48 hrs by hematoxylin/eosin staining based microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
8. | ALA3807093 | Functional | Neuroprotective activity in hypoxic-ischemic Sprague-Dawley rat brain assessed as regular shape of nucleus at 30 mg/kg, ip administered 15 mins prior to examination measured after 48 hrs by transmission electron microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
9. | ALA3807094 | Functional | Neuroprotective activity in hypoxic-ischemic Sprague-Dawley rat brain assessed as reduction in disruption of cell organelles at 30 mg/kg, ip administered 15 mins prior to examination measured after 48 hrs by transmission electron microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
10. | ALA3807097 | Functional | Neuroprotective activity in hypoxic-ischemic ip dosed neonatal Sprague-Dawley rat brain assessed as decrease in MDA levels administered 15 mins prior to examination measured after 48 hrs by thiobarbituric acid method | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
11. | ALA3807098 | Functional | Neuroprotective activity in hypoxic-ischemic ip dosed neonatal Sprague-Dawley rat brain assessed as increase in SOD levels administered 15 mins prior to examination measured after 48 hrs by microplate reader based method | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
12. | ALA3807099 | Functional | Neuroprotective activity in hypoxic-ischemic ip dosed neonatal Sprague-Dawley rat brain assessed as increase in GSH-Px levels administered 15 mins prior to examination measured after 48 hrs by microplate reader based method | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
13. | ALA3807100 | Functional | Neuroprotective activity in hypoxic-ischemic ip dosed neonatal Sprague-Dawley rat brain assessed as increase in CAT levels administered 15 mins prior to examination measured after 48 hrs by microplate reader based method | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
14. | ALA3807101 | Functional | Neuroprotective activity in hypoxic-ischemic ip dosed neonatal Sprague-Dawley rat brain assessed as increase in T-AOC levels administered 15 mins prior to examination measured after 48 hrs by microplate reader based method | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature | |
15. | ALA3807103 | Functional | Neuroprotective activity in hypoxic-ischemic neonatal Sprague-Dawley rat brain assessed as reduction in interstitial edema at 30 mg/kg, ip administered 15 mins prior to examination measured after 48 hrs by hematoxylin/eosin staining based microscopic analysis | Rattus norvegicus | 1 | ALA3804780 | organism-based format | Scientific Literature |