# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3811618 | Binding | Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 mins | Homo sapiens | 8 | ALA3808300 | protein complex format | Scientific Literature | |
2. | ALA3811619 | Binding | Inhibition of purified human factor 10a using S2765 as substrate after 30 to 60 mins | Homo sapiens | 8 | ALA3808300 | single protein format | Scientific Literature | |
3. | ALA3811620 | Binding | Inhibition of purified human factor 11a after 30 to 60 mins | Homo sapiens | 8 | ALA3808300 | single protein format | Scientific Literature | |
4. | ALA3811621 | Binding | Inhibition of purified human thrombin after 30 to 60 mins | Homo sapiens | 8 | ALA3808300 | single protein format | Scientific Literature | |
5. | ALA3811622 | Binding | Inhibition of purified human trypsin after 30 to 60 mins | Homo sapiens | 8 | ALA3808300 | protein format | Scientific Literature | |
6. | ALA3811623 | Binding | Inhibition of purified human tissue kallikrein 1 using H-D-Val-Leu-Arg-AFC as substrate | Homo sapiens | 8 | ALA3808300 | single protein format | Scientific Literature | |
7. | ALA3887451 | Binding | In Vitro Assay: FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibitor were incubated for 15 min at 37° C. Reactions were initiated by the addition of human FX (range of concentrations). Preliminary experiments revealed that the plasma purified FX contains a residual amount of human FVIIa which could not be removed by affinity chromatography. The residual FVIIa is sufficient, when combined with PCPS, calcium and TF to catalyze the conversion of FX to Xa, and was increased by the addition of 5 pM human FVIIa. FXa in turn hydrolyses S2765, which was monitored for 60 min at 405 nm. | Homo sapiens | 43 | ALA3886326 | cell-free format | BindingDB Database |