# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3817030 | B | Displacement of [3H]TO901317 from LXRalpha ligand binding domain (unknown origin) after 30 mins by liquid scintillation counting | Homo sapiens | 11 | ALA3813625 | single protein format | Scientific Literature | |
2. | ALA3817031 | B | Displacement of [3H]TO901317 from LXRbeta ligand binding domain (unknown origin) after 30 mins by liquid scintillation counting | Homo sapiens | 11 | ALA3813625 | single protein format | Scientific Literature | |
3. | ALA3817032 | B | Agonist activity at human LXRalpha ligand binding domain(167 to 447 residues) transfected in HEK293 cells after 16 hrs by Gal4-luciferase reporter gene assay | Homo sapiens | 11 | ALA3813625 | cell-based format | Scientific Literature | |
4. | ALA3817033 | B | Agonist activity at human LXRbeta ligand binding domain(155 to 460 residues) transfected in HEK293 cells after 16 hrs by Gal4-luciferase reporter gene assay | Homo sapiens | 11 | ALA3813625 | cell-based format | Scientific Literature | |
5. | ALA3817034 | B | Selectivity ratio of Ki for LXRalpha ligand binding domain (unknown origin) to Ki for LXRbeta ligand binding domain (unknown origin) | Homo sapiens | 10 | ALA3813625 | assay format | Scientific Literature | |
6. | ALA3817035 | A | Half life in human liver microsomes | Homo sapiens | 4 | ALA3813625 | tissue-based format | Scientific Literature | |
7. | ALA3817036 | A | Half life in rat liver microsomes | Rattus norvegicus | 7 | ALA3813625 | tissue-based format | Scientific Literature | |
8. | ALA3817037 | A | Half life in mouse liver microsomes | Mus musculus | 5 | ALA3813625 | tissue-based format | Scientific Literature | |
9. | ALA3817038 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression after 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
10. | ALA3817039 | B | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
11. | ALA3817040 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 1 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
12. | ALA3817041 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 2 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
13. | ALA3817042 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 5 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
14. | ALA3817043 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 16 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
15. | ALA3817044 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 50 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
16. | ALA3817045 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 158 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
17. | ALA3817046 | B | Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 500 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
18. | ALA3817048 | B | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 1 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
19. | ALA3817049 | B | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 2 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature | |
20. | ALA3817050 | B | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 6 nM after 24 hrs by RT-PCR analysis relative to control | Homo sapiens | 1 | ALA3813625 | cell-based format | Scientific Literature |