# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3816043 | B | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay | Mus musculus | 36 | cell-based format | Scientific Literature | ||
2. | ALA3816044 | B | Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay | Mus musculus | 36 | cell-based format | Scientific Literature | ||
3. | ALA3816046 | B | Intrinsic activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay relative to diF-C3-ph-o-O-C11 | Mus musculus | 36 | cell-based format | Scientific Literature | ||
4. | ALA3816047 | B | Agonist activity at mouse GPR174 expressed in HEK293FT cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay | Mus musculus | 12 | cell-based format | Scientific Literature | ||
5. | ALA3816048 | F | Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il assessed as increase in intracellular calcium levels at 1 uM measured after 35 secs by calcium 5 dye based fluorescence microplate reader method in presence of probenecid | Mus musculus | 6 | cell-based format | Scientific Literature | ||
6. | ALA3816049 | B | Agonist activity at mouse P2Y10 receptor expressed in rat McA-RH7777 cells assessed as induction of actin stress fiber formation at 100 nM after 30 mins by Alexa fluor 594-labelled phalloidin/DAPI staining based fluorescence microscopy | Mus musculus | 8 | cell-based format | Scientific Literature | ||
7. | ALA3816050 | B | Selectivity ratio of EC50 for mouse P2Y10 receptor expressed in HEK293A cells to EC50 for mouse GPR34 expressed in HEK293A cells | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA4014236 | B | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr | Mus musculus | 36 | cell-based format | Scientific Literature | ||
9. | ALA4014237 | B | Intrinsic activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/iL assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr relative to O-(Hydroxy(((2R,3R)-2-(((3-(2-((3-phenoxybenzyl)oxy)phenyl)- propanoyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)phosphoryl)- L-serine | Mus musculus | 30 | cell-based format | Scientific Literature | ||
10. | ALA4014238 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
11. | ALA4014239 | B | Intrinsic activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr relative to O-(Hydroxy(((2R,3R)-2-(((3-(2-((3-phenoxybenzyl)oxy)phenyl)- propanoyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)phosphoryl)- L-serine | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
12. | ALA4014240 | B | Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr relative to control | Mus musculus | 30 | cell-based format | Scientific Literature | ||
13. | ALA4014241 | B | Agonist activity at human GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of AP-TGFalpha release after 1 hr relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature |