# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3822105 | B | Binding affinity to E-cadherin in human OAW42 cells assessed as effect on PI3K/Akt signalling activation by measuring phosphorylation of Akt at Ser-473 residue at 1 to 2 mM by immunoblot analysis | Homo sapiens | 1 | ALA3817797 | cell-based format | Scientific Literature | |
2. | ALA3822106 | B | Inhibition of E-cadherin-Fc chimeric protein binding to E-cadherin in human OAW42 cells at 2 mM preincubated for 1 hr followed by E-cadherin-Fc addition measured after 2 hrs by ELISA relative to control | Homo sapiens | 2 | ALA3817797 | cell-based format | Scientific Literature | |
3. | ALA3822107 | B | Inhibition of recombinant N-cadherin-Fc chimeric protein (unknown origin) homodimerization at 10 uM preincubated for 30 mins followed by N-cadherin-Fc addition by surface plasmon resonance analysis relative to control | Homo sapiens | 2 | ALA3817797 | single protein format | Scientific Literature | |
4. | ALA3822108 | B | Inhibition of N-cadherin-Fc chimeric protein binding to N-cadherin in human SKOV3 cells at 2 mM preincubated for 1 hr followed by N-cadherin-Fc addition measured after 2 hrs by ELISA relative to control | Homo sapiens | 2 | ALA3817797 | cell-based format | Scientific Literature | |
5. | ALA3822109 | B | Inhibition of N-cadherin-Fc chimeric protein binding to N-cadherin in human SKOV3 cells at 1 mM preincubated for 1 hr followed by N-cadherin-Fc addition measured after 2 hrs by ELISA relative to control | Homo sapiens | 2 | ALA3817797 | cell-based format | Scientific Literature |