# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3819809 | B | Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density at 100 uM relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
2. | ALA3819942 | F | Antinociceptive activity in mouse assessed as inhibition of acetic acid-induced writhes administered 15 mins before acetic acid challenge and measured after 15 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
3. | ALA3993345 | B | Agonist activity at TASK3 (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA3993348 | B | Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA3993349 | B | Agonist activity at human TREK1 expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
6. | ALA3993351 | B | Agonist activity at human TREK1 expressed in xenopus oocytes assessed as increase in K+ current at 20 uM measured at 0 mV by double microelectrode method relative to control | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
7. | ALA3993354 | F | Antinociceptive activity in CD1 mouse assessed as inhibition of acetic acid-induced writhes at 10 mg/kg, sc pretreated for 15 mins followed by acetic acid challenge measured within 20 mins relative to control | Mus musculus | 53 | organism-based format | Scientific Literature | ||
8. | ALA3993357 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 56 | organism-based format | Scientific Literature | ||
9. | ALA3993358 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 56 | organism-based format | Scientific Literature | ||
10. | ALA3993359 | F | Antinociceptive activity in wild-type C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
11. | ALA3993360 | F | Antinociceptive activity in wild-type C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
12. | ALA3993361 | F | Antinociceptive activity in TREK1 deficient C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
13. | ALA3993362 | F | Antinociceptive activity in TREK1 deficient C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
14. | ALA3993363 | F | In vivo activation of TREK1 in C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
15. | ALA3993364 | F | In vivo activation of TREK1 in C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
16. | ALA3993365 | B | Agonist activity at TREK-2 (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA3993370 | A | Drug level in rat liver microsomes treated with at 40 mM (E)-ethyl 2-cyano-3-(furan-3-yl)acrylate measured after 24 hrs by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature |