# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3819815 | B | Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents at 100 uM relative to control | Homo sapiens | 3 | ALA3817738 | cell-based format | Scientific Literature | |
2. | ALA3819816 | B | Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents | Homo sapiens | 3 | ALA3817738 | cell-based format | Scientific Literature | |
3. | ALA3993349 | B | Agonist activity at human TREK1 expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 29 | ALA3992520 | cell-based format | Scientific Literature | |
4. | ALA3993357 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 56 | ALA3992520 | organism-based format | Scientific Literature | |
5. | ALA3993358 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 56 | ALA3992520 | organism-based format | Scientific Literature | |
6. | ALA4419063 | B | Activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 31 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
7. | ALA4419064 | B | Activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay relative to untreated control | Homo sapiens | 7 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
8. | ALA4419071 | B | Reversible modulatory activity at K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 100 uM at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
9. | ALA4419084 | B | Activation of K2P10.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
10. | ALA4419095 | B | Activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 400 uM by two-electrode voltage clamp assay | Homo sapiens | 3 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
11. | ALA4419098 | B | Activation of Kv7.2 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
12. | ALA4419103 | B | Activation of K2P10.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 500 uM at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
13. | ALA4419106 | B | Activation of K2P3.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 500 uM at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
14. | ALA4419107 | B | Activation of Kv7.2 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 500 uM by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
15. | ALA4421806 | B | Activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 30 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
16. | ALA4421811 | B | Activation of K2P10.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
17. | ALA4421812 | B | Selectivity index, ratio of IC50 for inhibition of Trk1p (unknown origin) expressed in SGY1528 yeast cells assessed as inhibition of cell growth by alamar blue dye based assay to IC50 for inhibition of K2P2.1 (unknown origin) expressed in SGY1528 yeast cells assessed as inhibition of cell growth by alamar blue dye based assay | Homo sapiens | 2 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
18. | ALA4421820 | B | Inhibition of K2P2.1 (unknown origin) expressed in SGY1528 yeast cells assessed as inhibition of cell growth at 10 uM incubated for 24 hrs by alamar blue dye based assay relative to control | Homo sapiens | 5 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
19. | ALA4421824 | B | Activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at +40 mV holding potential at 400 uM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
20. | ALA4421828 | B | Reversible activation of K2P2.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 100 uM at -80 mV holding potential by two-electrode voltage clamp assay relative to control | Homo sapiens | 1 | ALA4421719 | cell-based format | Patent Bioactivity Data |