| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3820948 | Binding | Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay | Homo sapiens | 26 | ALA3817726 | assay format | Scientific Literature | |
| 2. | ALA3820950 | Binding | Selectivity for human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) over LCK (unknown origin) | Homo sapiens | 18 | ALA3817726 | assay format | Scientific Literature | |
| 3. | ALA3820951 | Binding | Inhibition of PAK1/2 in human EBC1 cells assessed as phosphorylation of MEK1 at serine 298 after 2 hrs by HTRF assay | Homo sapiens | 18 | ALA3817726 | cell-based format | Scientific Literature | |
| 4. | ALA3820952 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 | 10 | ALA3817726 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA3820953 | Physicochemical | Kinetic solubility of the compound at pH 7.4 | 10 | ALA3817726 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA3820954 | ADME | Apparent permeability across apical to basolateral side in MDCK cells at 10 uM after 60 mins | Canis lupus familiaris | 10 | ALA3817726 | cell-based format | Scientific Literature | |
| 7. | ALA3820956 | ADME | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in MDCK cells at 10 uM after 60 mins | Canis lupus familiaris | 10 | ALA3817726 | cell-based format | Scientific Literature |
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