# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3822282 | Unassigned | Ratio of fCmax associated with acute adverse effect in mouse at 25 to 50 mg/kg, po to IC50 for PAK1/2-mediated phosphorylation of MEK1 at serine 298 in human EBC1 cells | 1 | ALA3817726 | organism-based format | Scientific Literature | ||
2. | ALA3820369 | Binding | Inhibition of recombinant human full length GST-tagged KHS1 expressed in Baculovirus at 1 uM relative to control | Homo sapiens | 2 | ALA3817726 | assay format | Scientific Literature | |
3. | ALA3820370 | Binding | Inhibition of recombinant human full length GST-tagged SIK2 expressed in Baculovirus at 1 uM relative to control | Homo sapiens | 2 | ALA3817726 | assay format | Scientific Literature | |
4. | ALA3820371 | Binding | Inhibition of recombinant human full length GST-tagged PAK1 expressed in Baculovirus at 1 uM relative to control | Homo sapiens | 2 | ALA3817726 | assay format | Scientific Literature | |
5. | ALA3820373 | Binding | Inhibition of recombinant human full length GST-tagged PAK2 expressed in Baculovirus at 1 uM relative to control | Homo sapiens | 2 | ALA3817726 | assay format | Scientific Literature | |
6. | ALA3820375 | Binding | Inhibition of recombinant human full length His-tagged PAK3 expressed in Baculovirus at 1 uM relative to control | Homo sapiens | 2 | ALA3817726 | assay format | Scientific Literature | |
7. | ALA3820387 | Binding | Inhibition of recombinant human 5-HT1A receptor expressed in HEK293 cells at 10 uM relative to control | Homo sapiens | 1 | ALA3817726 | cell-based format | Scientific Literature | |
8. | ALA3820948 | Binding | Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay | Homo sapiens | 26 | ALA3817726 | assay format | Scientific Literature | |
9. | ALA3820951 | Binding | Inhibition of PAK1/2 in human EBC1 cells assessed as phosphorylation of MEK1 at serine 298 after 2 hrs by HTRF assay | Homo sapiens | 18 | ALA3817726 | cell-based format | Scientific Literature | |
10. | ALA3820957 | Binding | Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay | Homo sapiens | 10 | ALA3817726 | single protein format | Scientific Literature | |
11. | ALA3820964 | ADME | Fraction unbound in mouse plasma at 25 to 50 mg/kg, po | Mus musculus | 1 | ALA3817726 | organism-based format | Scientific Literature | |
12. | ALA3821128 | ADME | Cmax associated with acute adverse effect in mouse at 25 to 50 mg/kg, po | Mus musculus | 1 | ALA3817726 | organism-based format | Scientific Literature | |
13. | ALA3821137 | ADME | fCmax associated with acute adverse effect in mouse at 25 to 50 mg/kg, po | Mus musculus | 1 | ALA3817726 | organism-based format | Scientific Literature |