# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3820761 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature | |
2. | ALA3820762 | ADME | Half life in human liver microsomes assessed as CYP-mediated compound degradation at 1 uM by LC-MS analysis | Homo sapiens | 10 | ALA3817843 | tissue-based format | Scientific Literature | |
3. | ALA3821519 | Functional | Negative inotropic activity in potassium depolarized guinea pig left atrium assessed as reduction in developed tension at 10'-5 M after 30 mins | Cavia porcellus | 7 | ALA3817843 | assay format | Scientific Literature | |
4. | ALA3821524 | Functional | Negative inotropic activity in potassium depolarized guinea pig left atrium assessed as reduction in developed tension after 30 mins | Cavia porcellus | 27 | ALA3817843 | assay format | Scientific Literature | |
5. | ALA3821527 | Functional | Negative chronotropic activity in potassium depolarized guinea pig right atrium assessed as reduction in atrial rate at 10'-4 M after 30 mins | Cavia porcellus | 9 | ALA3817843 | assay format | Scientific Literature | |
6. | ALA3821530 | Functional | Vasorelaxant activity in potassium depolarized guinea pig aorta assessed as inhibition of calcium-induced contraction at 10'-4 M after 30 mins | Cavia porcellus | 22 | ALA3817843 | tissue-based format | Scientific Literature | |
7. | ALA3821541 | ADME | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature | |
8. | ALA3821691 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature | |
9. | ALA3821692 | ADME | Intrinsic clearance in human liver microsomes at 1 uM after 2 to 60 mins by LC-MS analysis in presence of NADPH | Homo sapiens | 10 | ALA3817843 | tissue-based format | Scientific Literature | |
10. | ALA3821693 | ADME | Stability in human liver microsomes at 1 uM after 2 to 60 mins by LC-MS analysis in absence of NADPH | Homo sapiens | 10 | ALA3817843 | tissue-based format | Scientific Literature | |
11. | ALA3821694 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature | |
12. | ALA3821695 | ADME | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature | |
13. | ALA3821882 | ADME | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysis | Homo sapiens | 11 | ALA3817843 | tissue-based format | Scientific Literature |