| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3821629 | B | Binding affinity to Zn2+ using ZnCl2 at 20 uM after 5 mins by spectrophotometry | 7 | assay format | Scientific Literature | |||
| 2. | ALA3821630 | B | Binding affinity to Fe2+ using FeCl2 at 20 uM after 5 mins by spectrophotometry | 7 | assay format | Scientific Literature | |||
| 3. | ALA3821631 | B | Binding affinity to Ca2+ using CaCl2 at 20 uM after 5 mins by spectrophotometry | 7 | assay format | Scientific Literature | |||
| 4. | ALA3821632 | B | Binding affinity to Mn2+ using MnCl2 at 20 uM after 5 mins by spectrophotometry | 7 | assay format | Scientific Literature | |||
| 5. | ALA3821633 | B | Binding affinity to Mg2+ using MgSO4 at 20 uM after 5 mins by spectrophotometry | 7 | assay format | Scientific Literature | |||
| 6. | ALA3821635 | B | Binding affinity to Cu2+ using CuCl2 at 20 uM after 5 mins by spectrophotometric titration assay | 3 | assay format | Scientific Literature | |||
| 7. | ALA3821636 | B | Binding affinity to amyloid beta (1 to 40) (unknown origin) by tyrosine fluorimetric titration assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 8. | ALA3821637 | B | Inhibition of Cu2+-amyloid beta (1 to 40) catalyzed generation of hydroxyl radical assessed as 7-hrdroxy-CCA formation at 2 equiv preincubated for 1 hr followed by CCA addition measured over 60 mins by fluorescence assay | 7 | assay format | Scientific Literature | |||
| 9. | ALA3821638 | B | Inhibition of Cu2+-amyloid beta (1 to 40) catalyzed generation of hydroxyl radical assessed as rate of radical formation per min at 2 equiv preincubated for 1 hr followed by CCA addition measured over 60 mins by CCA based fluorescence assay (Rvb = 13 +/- 0.2 a.u.) | 7 | assay format | Scientific Literature | |||
| 10. | ALA3821639 | P | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometry | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA3821640 | U | Ratio of resveratrol IC50 to compound IC50 for DPPH free radical scavenging activity | 7 | assay format | Scientific Literature | |||
| 12. | ALA3821641 | P | Antioxidant activity assessed as AAPH radical scavenging activity preincubated for 30 mins followed by AAPH addition measured after 60 mins by ORAC assay | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA3821642 | U | Ratio of resveratrol IC50 to compound IC50 for AAPH radical scavenging activity | 7 | assay format | Scientific Literature | |||
| 14. | ALA3821643 | B | Inhibition of Cu2+-induced amyloid beta (1 to 40) aggregation at 100 uM preincubated for 5 mins followed by amyloid beta (1 to 40) addition measured after 18 days at pH 6.60 by thioflavin-T fluorescence assay | 5 | assay format | Scientific Literature | |||
| 15. | ALA3821644 | B | Inhibition of Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM preincubated for 5 mins followed by amyloid beta (1 to 40) addition measured after 3 days at pH 6.60 by thioflavin-T fluorescence assay | 7 | assay format | Scientific Literature | |||
| 16. | ALA3821645 | B | Inhibition of Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM preincubated for 5 mins followed by amyloid beta (1 to 40) addition measured after 7 days at pH 6.60 by thioflavin-T fluorescence assay | 7 | assay format | Scientific Literature | |||
| 17. | ALA3821646 | B | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 3 days at pH 6.60 by thioflavin-T fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 18. | ALA3821647 | B | Inhibition of self-induced amyloid beta (1 to 40) (unknown origin) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 7 days at pH 6.60 by thioflavin-T fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 19. | ALA3821648 | B | Inhibition of preformed Cu2+-induced amyloid beta (1 to 40) fibril aggregation assessed as remaining fibril aggregates at 100 uM after 4 days at pH 6.60 by thioflavin-T fluorescence assay | 6 | assay format | Scientific Literature | |||
| 20. | ALA3821649 | B | Induction of preformed Cu2+-induced amyloid beta (1 to 40) fibril aggregation at 100 uM after 4 to 12 days by turbidity assay relative to control | 3 | assay format | Scientific Literature |
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