# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3821481 | Physicochemical | Kinetic solubility in 3% DMSO solution in PBS at 44 to 100 uM stirred for 5 mins by HPLC-MS/MS analysis | 1 | ALA3817782 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA3821482 | Binding | Binding affinity to human recombinant FGF2 treated for 4 mins measured after 10 mins by surface plasmon resonance spectroscopic analysis | Homo sapiens | 1 | ALA3817782 | single protein format | Scientific Literature | |
3. | ALA3821484 | Physicochemical | Kinetic solubility in 3% DMSO solution in PBS up to 30 uM stirred for 5 mins by HPLC-MS/MS analysis | 2 | ALA3817782 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3821485 | Binding | Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K1 cell adhesion incubated for 2 hrs by luciferase assay | Homo sapiens | 2 | ALA3817782 | cell-based format | Scientific Literature | |
5. | ALA3821487 | Binding | Inhibition of human recombinant FGF2 assessed as suppression of FGF2-stimulated FGFR1 phosphorylation in mouse LLC cells at 25 uM incubated for 20 mins by Western blot analysis | Homo sapiens | 1 | ALA3817782 | cell-based format | Scientific Literature | |
6. | ALA3821489 | Functional | Antiproliferative activity against mouse LLC cells incubated for 48 hrs by PI-staining based flow cytometry | Mus musculus | 2 | ALA3817782 | cell-based format | Scientific Literature | |
7. | ALA3821490 | Functional | Antiproliferative activity against human NCI-H520 cells incubated for 72 hrs by PI-staining based flow cytometry | Homo sapiens | 2 | ALA3817782 | cell-based format | Scientific Literature | |
8. | ALA3821493 | Physicochemical | Kinetic solubility in DMEM buffer/1% DMSO assessed as recovered drug level at 10 uM after 4 hrs by HPLC-MS/MS analysis | 2 | ALA3817782 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3821494 | Physicochemical | Dissociation constant, pKa of the compound in methanol-water mixture at 25 +/- 1 degC by potentiometric pH-metric method | 2 | ALA3817782 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3821498 | Functional | Antitumor activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as tumor growth inhibition at 7.5 mg/kg administered as oral gavage for 7 days daily relative to vehicle-treated control | Mus musculus | 2 | ALA3817782 | organism-based format | Scientific Literature | |
11. | ALA3821499 | Functional | Antiangiogenic activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as pale appearance at 7.5 mg/kg administered as oral gavage for 7 days daily | Mus musculus | 2 | ALA3817782 | organism-based format | Scientific Literature | |
12. | ALA3821500 | Toxicity | Toxicity in C57BL/6 mouse xenografted with mouse LLC cells assessed as effect on body weight at 7.5 mg/kg administered as oral gavage for 7 days daily | Mus musculus | 2 | ALA3817782 | organism-based format | Scientific Literature | |
13. | ALA3821501 | Toxicity | Toxicity in C57BL/6 mouse xenografted with mouse LLC cells assessed as effect on clinical parameters at 7.5 mg/kg administered as oral gavage for 7 days daily | Mus musculus | 2 | ALA3817782 | organism-based format | Scientific Literature | |
14. | ALA3821502 | ADME | Plasma concentration in C57BL/6 mouse at 7.5 mg/kg administered as single dose measured after 30 mins | Mus musculus | 2 | ALA3817782 | organism-based format | Scientific Literature | |
15. | ALA4838563 | Binding | Trapping activity at FGF in human KMS-11 cells assessed as inhibition of FGFR3 phosphorylation at 6 uM measured after 6 hrs by western blot analysis | Homo sapiens | 27 | ALA4837219 | cell-based format | Scientific Literature | |
16. | ALA4838564 | Functional | Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 8 | ALA4837219 | cell-based format | Scientific Literature | |
17. | ALA4838569 | Binding | Displacement of [3H]estradiol from human full length recombinant ERalpha expressed in baculovirus-infected Sf9 cells at 5 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | ALA4837219 | cell-based format | Scientific Literature | |
18. | ALA4838570 | Binding | Displacement of [3H]estradiol from human full length recombinant ERalpha expressed in baculovirus-infected Sf9 cells at 50 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | ALA4837219 | cell-based format | Scientific Literature | |
19. | ALA4838571 | Binding | Displacement of [3H]estradiol from human full length recombinant ERbeta expressed in baculovirus-infected Sf9 cells at 5 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | ALA4837219 | cell-based format | Scientific Literature | |
20. | ALA4838572 | Binding | Displacement of [3H]estradiol from human full length recombinant ERbeta expressed in baculovirus-infected Sf9 cells at 50 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | ALA4837219 | cell-based format | Scientific Literature |