# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3825093 | Binding | Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-8 and human EAAT3 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method | Homo sapiens | 16 | ALA3822422 | cell-based format | Scientific Literature | |
2. | ALA3825094 | Binding | Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-2 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method | Homo sapiens | 15 | ALA3822422 | cell-based format | Scientific Literature | |
3. | ALA3825097 | Binding | Antagonist activity at human iGluA1 receptor flip isoform expressed in CHO-S cells assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 NW dye based fluorescence imaging plate reader method | Homo sapiens | 15 | ALA3822422 | cell-based format | Scientific Literature | |
4. | ALA3825099 | ADME | Drug metabolism in human liver microsomes assessed as oxidative metabolite formation | Homo sapiens | 14 | ALA3822422 | tissue-based format | Scientific Literature | |
5. | ALA3825100 | ADME | Drug metabolism in rat liver microsomes assessed as oxidative metabolite formation | Rattus norvegicus | 14 | ALA3822422 | tissue-based format | Scientific Literature | |
6. | ALA3825105 | ADME | Clearance in rat | Rattus norvegicus | 14 | ALA3822422 | organism-based format | Scientific Literature | |
7. | ALA3825110 | ADME | Inhibition of human CYP1A2 | Homo sapiens | 9 | ALA3822422 | single protein format | Scientific Literature | |
8. | ALA3825111 | ADME | Induction of CYP1A2 in human hepatocytes at 0.2 to 20 uM compared to omeprazole | Homo sapiens | 4 | ALA3822422 | cell-based format | Scientific Literature |