# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3824694 | Toxicity | Toxicity in po dosed Sprague-Dawley rat assessed as motor impairment by inverted screen test | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
2. | ALA3825093 | Binding | Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-8 and human EAAT3 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method | Homo sapiens | 16 | ALA3822422 | cell-based format | Scientific Literature | |
3. | ALA3825094 | Binding | Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-2 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 AM dye based fluorescence imaging plate reader method | Homo sapiens | 15 | ALA3822422 | cell-based format | Scientific Literature | |
4. | ALA3825097 | Binding | Antagonist activity at human iGluA1 receptor flip isoform expressed in CHO-S cells assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluo-4 NW dye based fluorescence imaging plate reader method | Homo sapiens | 15 | ALA3822422 | cell-based format | Scientific Literature | |
5. | ALA3825098 | ADME | AUC in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
6. | ALA3825099 | ADME | Drug metabolism in human liver microsomes assessed as oxidative metabolite formation | Homo sapiens | 14 | ALA3822422 | tissue-based format | Scientific Literature | |
7. | ALA3825100 | ADME | Drug metabolism in rat liver microsomes assessed as oxidative metabolite formation | Rattus norvegicus | 14 | ALA3822422 | tissue-based format | Scientific Literature | |
8. | ALA3825105 | ADME | Clearance in rat | Rattus norvegicus | 14 | ALA3822422 | organism-based format | Scientific Literature | |
9. | ALA3825110 | ADME | Inhibition of human CYP1A2 | Homo sapiens | 9 | ALA3822422 | single protein format | Scientific Literature | |
10. | ALA3825278 | Functional | Anticonvulsant activity in po dosed Sprague-Dawley rat assessed as inhibition of pentylenetetrazole-induced clonic convulsions administered 30 mins prior to PTZ dosing measured over 30 mins | Rattus norvegicus | 2 | ALA3822422 | organism-based format | Scientific Literature | |
11. | ALA3825280 | ADME | Oral bioavailability in rat at 3 mg/kg | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
12. | ALA3825284 | ADME | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
13. | ALA3825285 | ADME | Clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
14. | ALA3825286 | ADME | AUC in rat at 3 mg/kg, po | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
15. | ALA3825287 | ADME | Tmax in rat at 3 mg/kg, po | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
16. | ALA3825288 | ADME | Cmax in rat at 3 mg/kg, po | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
17. | ALA3825289 | Functional | Potency index, ratio of perampanel ED50 to compound ED50 for inhibition of pentylenetetrazole-induced clonic convulsions in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
18. | ALA3825290 | Functional | Anticonvulsant activity in po dosed Sprague-Dawley rat assessed as inhibition of pentylenetetrazole-induced clonic convulsions at 1 mg/kg administered 30 mins prior to PTZ dosing measured over 30 mins | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
19. | ALA3825291 | Functional | Anticonvulsant activity in po dosed Sprague-Dawley rat assessed as inhibition of pentylenetetrazole-induced clonic convulsions at 3 mg/kg administered 30 mins prior to PTZ dosing measured over 30 mins | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature | |
20. | ALA3825292 | Functional | Anticonvulsant activity in po dosed Sprague-Dawley rat assessed as inhibition of pentylenetetrazole-induced clonic convulsions at 10 mg/kg administered 30 mins prior to PTZ dosing measured over 30 mins | Rattus norvegicus | 1 | ALA3822422 | organism-based format | Scientific Literature |