| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3825931 | A | Cytotoxicity against rat GH3 cells expressing TRE and luciferase gene assessed as cell viability | Rattus norvegicus | 2 | ALA3822419 | cell-based format | Scientific Literature | |
| 2. | ALA3825933 | B | Inhibition of Pseudomonas aeruginosa recombinant His-tagged CFTR inhibitory factor expressed in expressed in Top10 Escherichia coli cells assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5 mins followed by addition of CMNGC as substrate measured for 10 mins in presence of BSA by fluorescent-based assay | Pseudomonas aeruginosa | 29 | ALA3822419 | cell-based format | Scientific Literature | |
| 3. | ALA3825934 | A | Agonist activity at thyroid hormone receptor in rat GH3 cells expressing TRE measured after 24 hrs in presence of T3 by luciferase reporter gene assay | Rattus norvegicus | 4 | ALA3822419 | cell-based format | Scientific Literature | |
| 4. | ALA3825935 | A | Antagonist activity at thyroid hormone receptor in rat GH3 cells expressing TRE at 10 uM measured after 24 hrs in presence of T3 by luciferase reporter gene assay | Rattus norvegicus | 3 | ALA3822419 | cell-based format | Scientific Literature | |
| 5. | ALA3825936 | B | Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method | Homo sapiens | 4 | ALA3822419 | cell-based format | Scientific Literature | |
| 6. | ALA3825937 | B | Inhibition of recombinant human mEH expressed in baculovirus expression system assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5 mins followed by addition of CMNGC as substrate by fluorescent-based assay | Homo sapiens | 4 | ALA3822419 | assay format | Scientific Literature | |
| 7. | ALA3826004 | A | Half life in human liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA3822419 | tissue-based format | Scientific Literature | |
| 8. | ALA3826005 | A | Stability in rat GH3 cells expressing TRE and luciferase gene assessed as percentage remaining at 10 uM measured after 24 hrs | Rattus norvegicus | 3 | ALA3822419 | cell-based format | Scientific Literature | |
| 9. | ALA3826006 | P | Equilibrium solubility of the compound in sodium phosphate buffer at pH 7.4 measured after 24 hrs by LC-MS/MS analysis | 3 | ALA3822419 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA3826007 | A | Protein binding in Balb/c mouse plasma at 1 uM by rapid equilibrium dialysis method | Mus musculus | 4 | ALA3822419 | cell-free format | Scientific Literature | |
| 11. | ALA3826009 | A | Cytotoxicity against human CFBE cells at 10 uM by Cytotox 96 non-radioactive cytotoxicity assay | Homo sapiens | 2 | ALA3822419 | cell-based format | Scientific Literature | |
| 12. | ALA3826010 | B | Selectivity ratio of IC50 for recombinant human mEH to IC50 for Pseudomonas aeruginosa recombinant His-tagged CFTR inhibitory factor | 3 | ALA3822419 | assay format | Scientific Literature | ||
| 13. | ALA3826011 | B | Selectivity ratio of IC50 for recombinant human sEH to IC50 for Pseudomonas aeruginosa recombinant His-tagged CFTR inhibitory factor | 3 | ALA3822419 | assay format | Scientific Literature |
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