# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3830868 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA3826926 | cell-based format | Scientific Literature | |
2. | ALA3830869 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | ALA3826926 | cell-based format | Scientific Literature | |
3. | ALA3830871 | F | Binding affinity to mouse brain HDAC2 assessed as AUC for duration of target engagement at 10 mg/kg, ip | Mus musculus | 2 | ALA3826926 | organism-based format | Scientific Literature | |
4. | ALA3830872 | F | Binding affinity to mouse brain HDAC2 at 10 mg/kg, ip | Mus musculus | 2 | ALA3826926 | organism-based format | Scientific Literature | |
5. | ALA3830979 | B | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA3826926 | cell-based format | Scientific Literature | |
6. | ALA3830980 | B | Inhibition of full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | ALA3826926 | cell-based format | Scientific Literature | |
7. | ALA3830981 | B | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA3826926 | assay format | Scientific Literature | |
8. | ALA3830982 | B | Inhibition of full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | ALA3826926 | assay format | Scientific Literature | |
9. | ALA3831142 | B | Ratio of residence time for full length human recombinant HDAC2 expressed in baculovirus to residence time for C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus | Homo sapiens | 2 | ALA3826926 | assay format | Scientific Literature | |
10. | ALA3828941 | B | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as association rate constant after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA3826926 | assay format | Scientific Literature | |
11. | ALA3828942 | A | Stability in mouse plasma assessed as compound remaining at 5 uM after 5 hrs by UPLC-MS analysis | Mus musculus | 10 | ALA3826926 | cell-free format | Scientific Literature | |
12. | ALA3828943 | A | Stability in mouse liver microsomes assessed as compound remaining at 1 uM after 60 mins by UPLC-MS analysis | Mus musculus | 10 | ALA3826926 | tissue-based format | Scientific Literature | |
13. | ALA3828944 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as association rate constant after 60 mins by fluorescence assay | Homo sapiens | 4 | ALA3826926 | cell-based format | Scientific Literature | |
14. | ALA3828945 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as dissociation rate constant after 60 mins by fluorescence assay | Homo sapiens | 4 | ALA3826926 | cell-based format | Scientific Literature | |
15. | ALA3828946 | B | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as association rate constant after 60 mins by fluorescence assay | Homo sapiens | 4 | ALA3826926 | cell-based format | Scientific Literature | |
16. | ALA3828947 | B | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as dissociation rate constant after 60 mins by fluorescence assay | Homo sapiens | 4 | ALA3826926 | cell-based format | Scientific Literature | |
17. | ALA3828948 | B | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as dissociation rate constant after 60 mins by fluorescence assay | Homo sapiens | 4 | ALA3826926 | assay format | Scientific Literature | |
18. | ALA3828949 | F | Binding affinity to mouse brain HDAC1 at 10 mg/kg, ip | Mus musculus | 2 | ALA3826926 | organism-based format | Scientific Literature | |
19. | ALA3828958 | F | Binding affinity to mouse brain HDAC1 assessed as AUC for duration of target engagement at 10 mg/kg, ip | Mus musculus | 2 | ALA3826926 | organism-based format | Scientific Literature | |
20. | ALA3828959 | B | Inhibition of HDAC1/HDAC2 in mouse forebrain primary neuron assessed acetylation of H4K12 at 10 uM after 24 hrs by acumen microcytometric analysis | Mus musculus | 2 | ALA3826926 | assay format | Scientific Literature |