# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3830867 | A | AUC in Sprague-Dawley rat plasma at 1 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
2. | ALA3830868 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
3. | ALA3830869 | B | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
4. | ALA3830870 | F | Binding affinity to mouse brain HDAC3 assessed as AUC for duration of target engagement at 10 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA3830871 | F | Binding affinity to mouse brain HDAC2 assessed as AUC for duration of target engagement at 10 mg/kg, ip | Mus musculus | 2 | organism-based format | Scientific Literature | ||
6. | ALA3830872 | F | Binding affinity to mouse brain HDAC2 at 10 mg/kg, ip | Mus musculus | 2 | organism-based format | Scientific Literature | ||
7. | ALA3830979 | B | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
8. | ALA3830980 | B | Inhibition of full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
9. | ALA3830981 | B | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
10. | ALA3830982 | B | Inhibition of full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
11. | ALA3831142 | B | Ratio of residence time for full length human recombinant HDAC2 expressed in baculovirus to residence time for C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus | Homo sapiens | 2 | assay format | Scientific Literature | ||
12. | ALA3831143 | B | Inhibition of N-terminal GST-tagged and C-terminal His-tagged human recombinant HDAC4 (627 to 1084 residues ) expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA3831144 | B | Inhibition of N-terminal GST-tagged full length human recombinant HDAC5 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA3828937 | B | Inhibition of human recombinant HDAC6 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA3828938 | B | Inhibition of N-terminal GST-tagged human recombinant HDAC7 (518 to end residues) expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA3828939 | B | Inhibition of C-terminal His-tagged full length human recombinant HDAC8 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA3828940 | B | Inhibition of C-terminal His-tagged human recombinant HDAC9 (604 to 1066 residues) expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA3828941 | B | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as association rate constant after 60 mins by fluorescence assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
19. | ALA3828942 | A | Stability in mouse plasma assessed as compound remaining at 5 uM after 5 hrs by UPLC-MS analysis | Mus musculus | 10 | cell-free format | Scientific Literature | ||
20. | ALA3828943 | A | Stability in mouse liver microsomes assessed as compound remaining at 1 uM after 60 mins by UPLC-MS analysis | Mus musculus | 10 | tissue-based format | Scientific Literature |