| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3829382 | F | Attenuation of methicillin-resistant Staphylococcus aureus Mu 50 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial survival in liver at 200 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
| 2. | ALA3829383 | B | Inhibition of diapophytoene desaturase in Staphylococcus aureus Newman assessed as 4,4'-diapophytoene formation by HPLC method | Staphylococcus aureus subsp. aureus str. Newman | 2 | ALA3826951 | single protein format | Scientific Literature | |
| 3. | ALA3829384 | B | Inhibition of diapophytoene desaturase in Staphylococcus aureus Newman assessed as reduction in staphyloxanthin pigment formation after 48 hrs by spectrophotometry | Staphylococcus aureus subsp. aureus str. Newman | 36 | ALA3826951 | single protein format | Scientific Literature | |
| 4. | ALA3829511 | B | Inhibition of 6x-His-tagged Staphylococcus aureus diapophytoene desaturase expressed in Escherichia coli BL21 (DE3) using diapophytoene substrate after overnight incubation | Staphylococcus aureus | 4 | ALA3826951 | assay format | Scientific Literature | |
| 5. | ALA3829512 | P | Aqueous solubility of the compound in water after 24 hrs by HPLC method | 4 | ALA3826951 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA3829513 | B | Inhibition of diapophytoene desaturase in methicillin-resistant Staphylococcus aureus USA300 LAC assessed as reduction in staphyloxanthin pigment formation after 48 hrs by spectrophotometry | Staphylococcus aureus LAC | 1 | ALA3826951 | assay format | Scientific Literature | |
| 7. | ALA3829514 | B | Inhibition of diapophytoene desaturase in methicillin-resistant Staphylococcus aureus USA400 MW2 assessed as reduction in staphyloxanthin pigment formation after 48 hrs by spectrophotometry | Staphylococcus aureus subsp. aureus MW2 | 1 | ALA3826951 | assay format | Scientific Literature | |
| 8. | ALA3829515 | B | Inhibition of diapophytoene desaturase in methicillin-resistant Staphylococcus aureus Mu 50 assessed as reduction in staphyloxanthin pigment formation after 48 hrs by spectrophotometry | Staphylococcus aureus subsp. aureus Mu50 | 1 | ALA3826951 | assay format | Scientific Literature | |
| 9. | ALA3829516 | A | Effect on Staphylococcus aureus Newman growth at 0.2 mM after overnight incubation by plate reader method | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 10. | ALA3830003 | A | Effect on methicillin-resistant Staphylococcus aureus USA400 MW2 growth at 0.05 mM after overnight incubation by plate reader method | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 11. | ALA3830004 | A | Effect on methicillin-resistant Staphylococcus aureus USA300 LAC growth at 0.2 mM after overnight incubation by plate reader method | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 12. | ALA3830005 | A | Effect on methicillin-resistant Staphylococcus aureus Mu 50 growth at 0.05 mM after overnight incubation by plate reader method | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 13. | ALA3830006 | F | Sensitization of Staphylococcus aureus Newman to H2O2-induced killing assessed as cell survival at 1 uM pre-incubated for for 24 hrs before H2O2 exposure for 30 mins by serial dilution method (Rvb = 30.43%) | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature | |
| 14. | ALA3830007 | F | Sensitization of methicillin-resistant Staphylococcus aureus USA400 MW2 to H2O2-induced killing assessed as cell survival at 1 uM pre-incubated for 24 hrs before H2O2 exposure for 30 mins by serial dilution method (Rvb = 14.17%) | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 15. | ALA3830008 | F | Sensitization of methicillin-resistant Staphylococcus aureus USA300 LAC to H2O2-induced killing assessed as cell survival at 1 uM pre-incubated for 24 hrs before H2O2 exposure for 30 mins by serial dilution method (Rvb = 15.83%) | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature | |
| 16. | ALA3830009 | F | Sensitization of methicillin-resistant Staphylococcus aureus Mu 50 to H2O2-induced killing assessed as cell survival at 1 uM pre-incubated for 24 hrs before H2O2 exposure for 30 mins by serial dilution method (Rvb = 30.67%) | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature | |
| 17. | ALA3830010 | F | Sensitization of Staphylococcus aureus Newman to H2O2-induced cell killing assessed as bacterial killing at 1 uM pre-incubated for 24 hrs before H2O2 exposure for 30 mins relative to control | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature | |
| 18. | ALA3830011 | F | Sensitization of Staphylococcus aureus Newman to human whole blood assessed as cell survival at 1 uM after 6 hrs by serial dilution method (Rvb = 26.67%) | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature | |
| 19. | ALA3830012 | F | Sensitization of methicillin-resistant Staphylococcus aureus USA400 MW2 to human whole blood assessed as cell survival at 1 uM after 6 hrs by serial dilution method (Rvb = 10.8%) | Staphylococcus aureus | 1 | ALA3826951 | organism-based format | Scientific Literature | |
| 20. | ALA3830013 | F | Sensitization of methicillin-resistant Staphylococcus aureus USA300 LAC to human whole blood assessed as cell survival at 1 uM after 6 hrs by serial dilution method (Rvb = 12.17%) | Staphylococcus aureus | 1 | ALA3826951 | assay format | Scientific Literature |
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