| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3829093 | B | Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition | Staphylococcus aureus | 9 | cell-based format | Scientific Literature | ||
| 2. | ALA3829094 | B | Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition | Escherichia coli | 9 | cell-based format | Scientific Literature | ||
| 3. | ALA3829095 | B | Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 4. | ALA3829096 | F | Antibacterial activity against Staphylococcus aureus ATCC 43300 incubated for 18 hrs by presto blue reagent based micro dilution broth assay | Staphylococcus aureus | 10 | organism-based format | Scientific Literature | ||
| 5. | ALA3829097 | F | Antibacterial activity against Escherichia coli ATCC 25922 by alamar blue reagent based micro dilution broth assay | Escherichia coli | 10 | organism-based format | Scientific Literature | ||
| 6. | ALA3829098 | F | Antibacterial activity against Escherichia coli NR698 harboring imp gene deletion mutant by alamar blue reagent based micro dilution broth assay | Escherichia coli | 10 | organism-based format | Scientific Literature | ||
| 7. | ALA3829099 | F | Bactericidal activity against Staphylococcus aureus ATCC 43300 | Staphylococcus aureus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA3829100 | F | Ratio of MBC=>99.9 to MIC for Staphylococcus aureus ATCC 43300 | Staphylococcus aureus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA3829101 | A | Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 10. | ALA3829108 | A | Cytotoxicity against human HepG2 cells at 100 uM after 4 hrs by alamar blue assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 11. | ALA3829109 | A | Cytotoxicity against HDF at 100 uM after 4 hrs by alamar blue assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 12. | ALA3829114 | F | Ratio of MIC for Escherichia coli ATCC 25922 to MIC for Escherichia coli NR698 harboring imp gene deletion mutant | 8 | assay format | Scientific Literature | |||
| 13. | ALA3829115 | F | Antibacterial activity against Escherichia coli JW0451 harboring AcrB gene deletion mutant by alamar blue reagent based micro dilution broth assay | Escherichia coli | 8 | organism-based format | Scientific Literature | ||
| 14. | ALA3829116 | F | Antibacterial activity against Escherichia coli harboring macB gene deletion mutant by alamar blue reagent based micro dilution broth assay | Escherichia coli | 8 | organism-based format | Scientific Literature | ||
| 15. | ALA3829117 | F | Antibacterial activity against Escherichia coli harboring emrB gene deletion mutant by alamar blue reagent based micro dilution broth assay | Escherichia coli | 8 | organism-based format | Scientific Literature | ||
| 16. | ALA3829118 | F | Antibacterial activity against Escherichia coli harboring acrF gene deletion mutant by alamar blue reagent based micro dilution broth assay | Escherichia coli | 8 | organism-based format | Scientific Literature | ||
| 17. | ALA4478710 | B | Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihydrofolate substrate addition | Staphylococcus aureus | 13 | single protein format | Scientific Literature | ||
| 18. | ALA4478711 | B | Inhibition of TMP/methicillin-resistant Staphylococcus aureus recombinant DHFR F98Y mutant expressed in Escherichia coli BL21 (DE3) cells assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihydrofolate substrate addition | Staphylococcus aureus | 13 | cell-based format | Scientific Literature | ||
| 19. | ALA4478712 | B | Inhibition of TMP/methicillin-resistant Staphylococcus aureus recombinant DHFR H30N mutant expressed in Escherichia coli BL21 (DE3) cells assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihydrofolate substrate addition | Staphylococcus aureus | 13 | cell-based format | Scientific Literature | ||
| 20. | ALA4478713 | B | Inhibition of TMP/methicillin-resistant Staphylococcus aureus recombinant DHFR H149R mutant expressed in Escherichia coli BL21 (DE3) cells assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihydrofolate substrate addition | Staphylococcus aureus | 13 | cell-based format | Scientific Literature |
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