# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3829199 | B | Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay relative to resiquimod | Homo sapiens | 13 | ALA3826928 | cell-based format | Scientific Literature | |
2. | ALA3829200 | B | Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA3826928 | cell-based format | Scientific Literature | |
3. | ALA3829202 | B | Agonist activity at human TLR8 expressed in HEK293 cells up to 30 uM incubated for 6 hrs by luciferase reporter gene assay relative to resiquimod | Homo sapiens | 13 | ALA3826928 | cell-based format | Scientific Literature | |
4. | ALA3829203 | B | Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrs | Mus musculus | 13 | ALA3826928 | cell-based format | Scientific Literature | |
5. | ALA3829204 | B | Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrs relative to resiquimod | Mus musculus | 13 | ALA3826928 | cell-based format | Scientific Literature | |
6. | ALA3829205 | B | Agonist activity at TLR7 in human PBMC assessed as induction of IL-6 secretion in supernatant after 18 hrs | Homo sapiens | 13 | ALA3826928 | single protein format | Scientific Literature | |
7. | ALA3829206 | B | Agonist activity at TLR7 in human PBMC assessed as induction of IL-6 secretion in supernatant after 18 hrs relative to resiquimod | Homo sapiens | 13 | ALA3826928 | single protein format | Scientific Literature | |
8. | ALA3829209 | P | Adsorption on alum in pH 6.5 histidine buffer assessed as compound adsorbed at 1 mg/ml incubated for 1 hr by LC-MS analysis relative to control | 5 | ALA3826928 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3829210 | P | Adsorption on alum in pH 6.5 histidine buffer assessed as compound adsorbed at 1 mg/ml incubated for 1 hr in presence of inorganic phosphate by LC-MS analysis | 4 | ALA3826928 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3829212 | P | Aqueous solubility of compound in pH 1.5 to 10 solution by potentiometric titration method | 2 | ALA3826928 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3829217 | B | Ratio of EC50 for TLR7 in Balb/c mouse splenocytes to EC50 for human TLR7 expressed in HEK293 cells | 13 | ALA3826928 | cell-based format | Scientific Literature | ||
12. | ALA3829218 | B | Ratio of EC50 for TLR7 in human PBMC to EC50 for human TLR7 expressed in HEK293 cells | Homo sapiens | 12 | ALA3826928 | cell-based format | Scientific Literature |