# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3875502 | Binding | Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assay | Homo sapiens | 48 | ALA3875159 | single protein format | Scientific Literature | |
2. | ALA3875503 | Binding | Binding affinity to human WDR5 by isothermal titration calorimetry | Homo sapiens | 3 | ALA3875159 | single protein format | Scientific Literature | |
3. | ALA3875505 | Binding | Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay | Homo sapiens | 4 | ALA3875159 | protein complex format | Scientific Literature | |
4. | ALA3875516 | Functional | Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein after 72 hrs by CCK8 assay | Homo sapiens | 21 | ALA3875159 | cell-based format | Scientific Literature | |
5. | ALA3875517 | Functional | Growth inhibition of human K562 cells at 35 uM after 7 days by MTS assay relative to control | Homo sapiens | 3 | ALA3875159 | cell-based format | Scientific Literature | |
6. | ALA3875518 | Functional | Growth inhibition of human THP1 cells at 35 uM after 7 days by MTS assay relative to control | Homo sapiens | 4 | ALA3875159 | cell-based format | Scientific Literature | |
7. | ALA4832186 | Binding | Displacement of 10mer-Thr-FAM probe from WDR5 (unknown origin) incubated for 30 mins by fluorescence polarizaton assay | Homo sapiens | 25 | ALA4831498 | single protein format | Scientific Literature | |
8. | ALA4832187 | Functional | Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as reduction in cell viability measured after 72 hrs by CCK8 assay | Homo sapiens | 12 | ALA4831498 | cell-based format | Scientific Literature | |
9. | ALA4832188 | Functional | Antiproliferative activity against human MOLM-13 cells harboring MLL-AF9 fusion protein assessed as reduction in cell viability measured after 72 hrs by CCK8 assay | Homo sapiens | 12 | ALA4831498 | cell-based format | Scientific Literature | |
10. | ALA4832189 | ADME | Cytotoxicity against HUVEC assessed as reduction in cell viability after 24 hrs by MTT assay | Homo sapiens | 12 | ALA4831498 | cell-based format | Scientific Literature | |
11. | ALA4832190 | ADME | Permeability of compound at pH 7.4 after 4 hrs by GIT PAMPA method | 12 | ALA4831498 | assay format | Scientific Literature | ||
12. | ALA4832191 | Physicochemical | Solubility of the compound at pH 7.4 by potentiometric titration method | 12 | ALA4831498 | small-molecule physicochemical format | Scientific Literature |