# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3876411 | B | Antagonist activity at mouse recombinant SRA extracellular domain expressed in baculovirus infected Sf21 insect cells assessed as inhibition of protein-induced reduction of IL2 gene promoter activation in anti CD3/CD28 antibody activated wild type C57BL/6 mouse B3Z T-cells at 50 uM after 5 hrs by beta-galactosidase reporter gene assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
2. | ALA3876413 | B | Antagonist activity at SRA in RM1-OVA tumor bearing wild type C57BL/6 mouse derived CD11bpositiveLy6ChighLy6Gnegative myeloid-derived suppressive cells co-cultured with splenocytes assessed as reduction in protein-mediated inhibition of anti CD3/CD28 antibody-induced T-cell activation by measuring IL-2 secretion at 10 to 20 uM pretreated for 2 hrs followed by splenocytes addition measured after 56 hrs by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
3. | ALA3876414 | B | Antagonist activity at SRA in RM1-OVA tumor bearing wild type C57BL/6 mouse derived CD11bpositiveLy6ChighLy6Gnegative myeloid-derived suppressive cells co-cultured with splenocytes assessed as reduction in protein-mediated inhibition of anti CD3/CD28 antibody-induced T-cell proliferation at 10 to 20 uM preincubated for 2 hrs followed by splenocytes addition measured after 72 hrs by [3H]-thymidine incorporation assay | Mus musculus | 3 | assay format | Scientific Literature | ||
4. | ALA4813813 | B | Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay | Homo sapiens | 45 | assay format | Scientific Literature |