| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3876688 | B | Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 2. | ALA3876689 | B | Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 3. | ALA4118523 | B | Inhibition of TAK1 (unknown origin) by LanthaScreen assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 4. | ALA4118525 | F | Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Mus musculus | 25 | cell-based format | Scientific Literature | ||
| 5. | ALA4118526 | F | Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 6. | ALA4118532 | F | Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 7. | ALA4118533 | F | Antiproliferative activity against human SKCO1 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA4118534 | F | Antiproliferative activity against human PANC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 9. | ALA4118535 | F | Antiproliferative activity against human AsPC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA4118536 | F | Antiproliferative activity against human SW156 cells harboring wild type KRAS after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 11. | ALA4118537 | F | Antiproliferative activity against human URMC6 cells harboring wild type KRAS after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 12. | ALA4118540 | B | Inhibition of biotin-labeled N-(2-(2-(2-(2-(4-(4-((4-((2-Acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide probe binding to TAK1 in human NCI-H358 cells at 10 uM after 6 hrs by immunoblot based competitive pull down assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 13. | ALA4119061 | B | Inhibition of TAK1 in RA patient-derived synovial fibroblasts assessed as inhibition of TNFalpha-induced cytokine secretion at 3 uM preincubated for 3 hrs followed by TNFalpha stimulation measured after 18 hrs by sandwich immunoassay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 14. | ALA4119062 | B | Inhibition of TAK1 in RA patient-derived synovial fibroblasts assessed as inhibition of IL-1alpha-induced cytokine secretion at 3 uM preincubated for 3 hrs followed by IL-1alpha stimulation measured after 18 hrs by sandwich immunoassay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 15. | ALA4119063 | B | Inhibition of TAK1 in RA patient-derived synovial fibroblasts assessed as inhibition of poly(I:C)-induced cytokine secretion at 3 uM preincubated for 3 hrs followed by poly(I:C) stimulation measured after 18 hrs by sandwich immunoassay | Homo sapiens | 5 | single protein format | Scientific Literature |
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