Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells at 100 uM measured after 60 mins by scintillation counting method relative to control
Anticonvulsant activity in ip dosed maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension by measuring time to peak effect
Anticonvulsant activity in maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension at 30 mg/kg, ip measured at 0.5 hrs post dose
Anticonvulsant activity in maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension at 300 mg/kg, ip measured at 0.5 hrs post dose
Anticonvulsant activity in maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension at 30 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension at 100 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in maximal electroshock induced seizure mouse model assessed as suppression in hindlimb tonic extension at 300 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in pentylenetetrazole induced seizure mouse model assessed as no observable episode of clonic convulsion of at least 5 secs at 30 mg/kg, ip measured at 0.5 hrs post dose
Anticonvulsant activity in pentylenetetrazole induced seizure mouse model assessed as no observable episode of clonic convulsion of at least 5 secs at 300 mg/kg, ip measured at 0.5 hrs post dose
Anticonvulsant activity in pentylenetetrazole induced seizure mouse model assessed as no observable episode of clonic convulsion of at least 5 secs at 30 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in pentylenetetrazole induced seizure mouse model assessed as no observable episode of clonic convulsion of at least 5 secs at 100 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in pentylenetetrazole induced seizure mouse model assessed as no observable episode of clonic convulsion of at least 5 secs at 300 mg/kg, ip measured at 4 hrs post dose
Anticonvulsant activity in 6-Hz induced seizure mouse model assessed as restoration of normal activity within 10 secs from stimulation at 100 mg/kg, ip at 32 mA measured at 0.25 hrs post dose
Anticonvulsant activity in 6-Hz induced seizure mouse model assessed as restoration of normal activity within 10 secs from stimulation at 100 mg/kg, ip at 44 mA measured at 0.25 hrs post dose
Anticonvulsant activity in 6-Hz induced seizure mouse model assessed as restoration of normal activity within 10 secs from stimulation at 100 mg/kg, ip at 32 mA measured at 0.5 hrs post dose