| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3876687 | B | Binding affinity to full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system assessed as labeling of Cys-174 residue after 1 hr by mass spectrometric analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA3876688 | B | Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 3. | ALA3876689 | B | Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 4. | ALA3876690 | B | Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assay | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 5. | ALA3876691 | B | Time-dependent inhibition of TAB1 fused TAK1 (unknown origin) using FAM-LRRKtide as substrate by mobility shift assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA3876693 | B | Selectivity ratio of IC50 for full length recombinant human His-tagged MEK1 expressed in baculovirus expression system to IC50 for full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA3876694 | B | Selectivity ratio of IC50 for full length recombinant human GST-tagged ERK2 expressed in Escherichia coli to IC50 for full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 8. | ALA3876702 | A | Half life in mouse liver microsomes by LC-MS/MS analysis | Mus musculus | 15 | tissue-based format | Scientific Literature | ||
| 9. | ALA4118523 | B | Inhibition of TAK1 (unknown origin) by LanthaScreen assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 10. | ALA4118524 | A | Antiproliferative activity against mouse BA/F3 cells after 72 hrs by CellTiter-Glo assay | Mus musculus | 17 | cell-based format | Scientific Literature | ||
| 11. | ALA4118525 | F | Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Mus musculus | 25 | cell-based format | Scientific Literature | ||
| 12. | ALA4118526 | F | Antiproliferative activity against mouse BA/F3 cells harboring KRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 13. | ALA4118527 | F | Antiproliferative activity against mouse BA/F3 cells harboring NRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4118528 | F | Antiproliferative activity against mouse BA/F3 cells harboring NRAS G12D mutant after 72 hrs in presence of IL-3 by CellTiter-Glo assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4118529 | F | Antiproliferative activity against human MOLM14 cells harboring FLT3-ITD mutant at 31.2 to 1000 nM after 72 hrs by CellTiter-Glo assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 16. | ALA4118530 | B | Inhibition of FLT3 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA4118531 | F | Antiproliferative activity against human NALM6 cells harboring NARS A146T mutant at 31.2 to 1000 nM after 72 hrs by CellTiter-Glo assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 18. | ALA4118532 | F | Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 19. | ALA4118533 | F | Antiproliferative activity against human SKCO1 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 20. | ALA4118534 | F | Antiproliferative activity against human PANC1 cells harboring KRAS G12D mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 9 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!