| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3875502 | B | Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assay | Homo sapiens | 48 | single protein format | Scientific Literature | ||
| 2. | ALA3875503 | B | Binding affinity to human WDR5 by isothermal titration calorimetry | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA3875504 | B | Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) at 30 uM by AlphaScreen assay relative to control | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 4. | ALA3875505 | B | Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay | Homo sapiens | 4 | protein complex format | Scientific Literature | ||
| 5. | ALA3875506 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me1 level at 5 uM after 7 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3875508 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me2 level after 7 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3875510 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression after 7 days by RT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3875511 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Meis-1 gene expression after 7 days by RT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3875512 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression at 2.5 uM after 7 days by RT-PCR method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3875513 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression at 10 uM after 7 days by RT-PCR method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3875514 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Meis-1 gene expression at 2.5 uM after 7 days by RT-PCR method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3875515 | B | Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Meis-1 gene expression at 10 uM after 7 days by RT-PCR method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3875516 | F | Antiproliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein after 72 hrs by CCK8 assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 14. | ALA3875517 | F | Growth inhibition of human K562 cells at 35 uM after 7 days by MTS assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3875518 | F | Growth inhibition of human THP1 cells at 35 uM after 7 days by MTS assay relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA3875520 | F | Induction of apoptosis in human MV4-11 cells harboring MLL-AF4 fusion protein after 72 hrs by Annexin-V/propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3875521 | F | Induction of apoptosis in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as viable cells at 2.5 uM after 72 hrs by Annexin-V/propidium iodide staining based flow cytometry (Rvb = 73.8%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3875522 | F | Induction of apoptosis in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as early apoptotic cells at 2.5 uM after 72 hrs by Annexin-V/propidium iodide staining based flow cytometry (Rvb = 4.45%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3875523 | F | Induction of apoptosis in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as late apoptotic cells at 2.5 uM after 72 hrs by Annexin-V/propidium iodide staining based flow cytometry (Rvb = 21.6%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3875524 | F | Induction of apoptosis in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as necrotic cells at 2.5 uM after 72 hrs by Annexin-V/propidium iodide staining based flow cytometry (Rvb = 0.15%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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