# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3865197 | Binding | Selectivity ratio of IC50 for recombinant human CaV 3.2 channel expressed in HEK293 cells to IC50 for recombinant human CaV 3.3 channel expressed in HEK293 cells | Homo sapiens | 1 | ALA3864167 | cell-based format | Scientific Literature | |
2. | ALA3865198 | Binding | Selectivity ratio of IC50 for recombinant human CaV 3.1 channel expressed in HEK293 cells to IC50 for recombinant human CaV 3.3 channel expressed in HEK293 cells | Homo sapiens | 1 | ALA3864167 | cell-based format | Scientific Literature | |
3. | ALA3865199 | Physicochemical | Solubility of the compound at pH 7 | 13 | ALA3864167 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3865200 | ADME | Solubility of the compound in fast state simulated intestinal fluid | 3 | ALA3864167 | assay format | Scientific Literature | ||
5. | ALA3865201 | ADME | Solubility of the compound in fed state simulated intestinal fluid | 3 | ALA3864167 | assay format | Scientific Literature | ||
6. | ALA3865202 | Physicochemical | Lipophilicity, logD of compund at pH 7.4 | 7 | ALA3864167 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3865203 | Binding | Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins followed by CaCl2 addition by fluo-4 dye-based FLIPR assay | Homo sapiens | 97 | ALA3864167 | cell-based format | Scientific Literature | |
8. | ALA3865204 | Binding | Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins followed by CaCl2 addition by fluo-4 dye-based FLIPR assay | Homo sapiens | 97 | ALA3864167 | cell-based format | Scientific Literature | |
9. | ALA3865205 | Binding | Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins followed by CaCl2 addition by fluo-4 dye-based FLIPR assay | Homo sapiens | 97 | ALA3864167 | cell-based format | Scientific Literature | |
10. | ALA3865206 | ADME | Intrinsic clearance in human liver microsomes at 1 uM up to 15 mins in presence of NADPH by LC-MS-MS analysis | Homo sapiens | 97 | ALA3864167 | tissue-based format | Scientific Literature | |
11. | ALA3865208 | ADME | Apparent permeability from apical side to basolateral side in MDCK1 cells expressing MDR1 | Canis lupus familiaris | 5 | ALA3864167 | cell-based format | Scientific Literature | |
12. | ALA3865209 | ADME | Apparent permeability from basolateral side to apical side in MDCK1 cells expressing MDR1 | Canis lupus familiaris | 5 | ALA3864167 | cell-based format | Scientific Literature | |
13. | ALA3865210 | ADME | Efflux ratio for apparent permeability in MDCK1 cells expressing MDR1 | Canis lupus familiaris | 5 | ALA3864167 | cell-based format | Scientific Literature | |
14. | ALA3865211 | Physicochemical | Dissociation constant, pKa of compound | 5 | ALA3864167 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3865212 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA3864167 | single protein format | Scientific Literature | |
16. | ALA3865213 | ADME | Cmax in Wistar rat at 100 mg/kg administered through oral gavage up to 24 hrs by LC-MS-MS analysis | Rattus norvegicus | 1 | ALA3864167 | organism-based format | Scientific Literature | |
17. | ALA3865214 | ADME | Tmax in Wistar rat at 100 mg/kg administered through oral gavage by LC-MS-MS analysis | Rattus norvegicus | 1 | ALA3864167 | organism-based format | Scientific Literature | |
18. | ALA3865215 | ADME | AUC in Wistar rat at 100 mg/kg administered through oral gavage up to 24 hrs by LC-MS-MS analysis | Rattus norvegicus | 1 | ALA3864167 | organism-based format | Scientific Literature | |
19. | ALA3865216 | ADME | Drug uptake in Wistar rat brain at 100 mg/kg, po after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3864167 | organism-based format | Scientific Literature | |
20. | ALA3865217 | ADME | Drug uptake in Wistar rat plasma at 100 mg/kg, po after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3864167 | organism-based format | Scientific Literature |