| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3873571 | B | Displacement of [3H]-Astemizole from human ERG expressed in HEK293 cell membranes at 1 uM by patch clamp assay | Homo sapiens | 1 | ALA3872236 | cell-based format | Scientific Literature | |
| 2. | ALA3873572 | B | Displacement of [3H]-Astemizole from human ERG expressed in HEK293 cell membranes at 10 uM by patch clamp assay | Homo sapiens | 1 | ALA3872236 | cell-based format | Scientific Literature | |
| 3. | ALA3873573 | B | Selectivity ratio of IC50 for human recombinant PGDS expressed in CHO cells to IC50 for human recombinant mPGES-1 expressed in CHO cells | Homo sapiens | 1 | ALA3872236 | cell-based format | Scientific Literature | |
| 4. | ALA3873574 | B | Selectivity ratio of IC50 for human recombinant PGIS expressed in CHO cells to IC50 for human recombinant mPGES-1 expressed in CHO cells | Homo sapiens | 1 | ALA3872236 | cell-based format | Scientific Literature | |
| 5. | ALA3873575 | B | Selectivity ratio of IC50 for human recombinant TXAS expressed in CHO cells to IC50 for human recombinant mPGES-1 expressed in CHO cells | Homo sapiens | 1 | ALA3872236 | cell-based format | Scientific Literature | |
| 6. | ALA3873577 | B | Inhibition of human recombinant mPGES-1 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 incubated for 10 mins followed by substrate addition measured after 1 min in presence of GSH | Homo sapiens | 33 | ALA3872236 | cell-based format | Scientific Literature | |
| 7. | ALA3873578 | B | Inhibition of mPGES-1 in human A549 cells assessed as reduction in interleukin-1 beta-induced PGE2 production incubated for 30 mins followed by IL-1beta stimulation for 16 to 20 hrs in presence of 2% fetal bovine serum by HTRF assay | Homo sapiens | 28 | ALA3872236 | cell-based format | Scientific Literature | |
| 8. | ALA3873579 | B | Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated followed by LPS stimulation for 20 to 24 hrs | Homo sapiens | 9 | ALA3872236 | tissue-based format | Scientific Literature | |
| 9. | ALA3873580 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 8 | ALA3872236 | tissue-based format | Scientific Literature | |
| 10. | ALA3873581 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 8 | ALA3872236 | tissue-based format | Scientific Literature | |
| 11. | ALA3873582 | A | Metabolic stability in guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Cavia porcellus | 8 | ALA3872236 | tissue-based format | Scientific Literature | |
| 12. | ALA3873583 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Mus musculus | 1 | ALA3872236 | tissue-based format | Scientific Literature | |
| 13. | ALA3873584 | A | Metabolic stability in dog liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Canis lupus familiaris | 1 | ALA3872236 | tissue-based format | Scientific Literature | |
| 14. | ALA3873585 | A | Metabolic stability in cynomolgus monkey liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Macaca fascicularis | 1 | ALA3872236 | tissue-based format | Scientific Literature | |
| 15. | ALA3873586 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 7 | ALA3872236 | tissue-based format | Scientific Literature | |
| 16. | ALA3873587 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 7 | ALA3872236 | tissue-based format | Scientific Literature | |
| 17. | ALA3873588 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 7 | ALA3872236 | tissue-based format | Scientific Literature | |
| 18. | ALA3873589 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 7 | ALA3872236 | tissue-based format | Scientific Literature | |
| 19. | ALA3873590 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM after 40 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 7 | ALA3872236 | tissue-based format | Scientific Literature | |
| 20. | ALA3873591 | A | Inhibition of CYP2D6 in human liver microsomes after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 1 | ALA3872236 | tissue-based format | Scientific Literature |
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