# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3854654 | Binding | Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydrolysis after 15 mins | Homo sapiens | 13 | ALA3853316 | protein complex format | Scientific Literature | |
2. | ALA3854655 | Binding | Inhibition of human factor 10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 11 | ALA3853316 | single protein format | Scientific Literature | |
3. | ALA3854656 | Binding | Inhibition of human factor 11a using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 11 | ALA3853316 | single protein format | Scientific Literature | |
4. | ALA3854657 | Binding | Inhibition of alpha-thrombin (unknown origin) using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 11 | ALA3853316 | single protein format | Scientific Literature | |
5. | ALA3854658 | Binding | Inhibition of trypsin (unknown origin) using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 11 | ALA3853316 | assay format | Scientific Literature | |
6. | ALA3854659 | Binding | Inhibition of human HK1 using H-D-Val-Leu-Arg-AFC as substrate assessed as release of AFC after 10 to 120 mins by spectrofluorimetric method | Homo sapiens | 13 | ALA3853316 | single protein format | Scientific Literature | |
7. | ALA3854660 | Binding | Inhibition of TF/factor 7a in human immunodepleted plasma assessed as concentration required to cause two fold prolongation of clotting time | Homo sapiens | 13 | ALA3853316 | cell-free format | Scientific Literature | |
8. | ALA3854661 | ADME | Permeability coefficient of the compound at 100 uM after 4 hrs by PAMPA | 13 | ALA3853316 | assay format | Scientific Literature | ||
9. | ALA3854662 | ADME | Half life in human liver microsomes | Homo sapiens | 5 | ALA3853316 | tissue-based format | Scientific Literature | |
10. | ALA3854663 | ADME | Half life in dog liver microsomes | Canis lupus familiaris | 5 | ALA3853316 | tissue-based format | Scientific Literature | |
11. | ALA3854664 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 5 | ALA3853316 | tissue-based format | Scientific Literature | |
12. | ALA3854665 | ADME | Oral bioavailability in dog at 1 mg/kg | Canis lupus familiaris | 5 | ALA3853316 | organism-based format | Scientific Literature | |
13. | ALA3854666 | Physicochemical | Dissociation constant, pKa of the compound in methanol/water by spectrophotometric titration method | 3 | ALA3853316 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3854667 | Binding | Inhibition of human factor 9a using methylsulfonyl-D-cyclohexylglycyl-Gly-Arg-AMC as substrate assessed as release of AMC after 10 to 120 mins by spectrofluorimetric method | Homo sapiens | 1 | ALA3853316 | single protein format | Scientific Literature | |
15. | ALA3854668 | Binding | Inhibition of human factor 12a using H-(D)-CHT-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | single protein format | Scientific Literature | |
16. | ALA3854669 | Binding | Inhibition of human plasma kallikrein using H-(D)-Pro-Phe-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | cell-free format | Scientific Literature | |
17. | ALA3854670 | Binding | Inhibition of human activated protein C using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | single protein format | Scientific Literature | |
18. | ALA3854671 | Binding | Inhibition of chymotrypsin (unknown origin) using MeO-SucArg-Pro-Tyr-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | assay format | Scientific Literature | |
19. | ALA3854672 | Binding | Inhibition of human plasmin using H-(D)-Val-Leu-LyspNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | single protein format | Scientific Literature | |
20. | ALA3854673 | Binding | Inhibition of human recombinant tPA using methylsulfonyl-D-cyclohexylalanylGly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method | Homo sapiens | 1 | ALA3853316 | single protein format | Scientific Literature |